Files

677834.pdf (831.33 KB)

Document type

Article

Version

Published version

Publication date

2014-05-08

Publication license

cc-by (c) Luque Gómez, Ana et al., 2014
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/125922

Usefulness of circulating microRNAs for the prediction of early preeclampsia at first-trimester of pregnancy

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1038/srep04882

Abstract

To assess the usefulness of circulating microRNAs (miRNAs) as non-invasive molecular biomarkers for early prediction of preeclampsia, a differential miRNA profiling analysis was performed in first-trimester pooled sera from 31 early preeclampsia patients, requiring delivery before 34 weeks of gestation, and 44 uncomplicated pregnancies using microfluidic arrays. Among a total of 754 miRNAs analyzed, the presence of 63 miRNAs (8%) was consistently documented in the sera from preeclampsia and control samples. Nevertheless, only 15 amplified miRNAs (2%) seemed to be differentially, although modestly, represented (fold change range: 0.4-1.4). After stem loop RT-qPCR from individual samples, the statistical analysis confirmed that none of the most consistent and differentially represented miRNAs (3 overrepresented and 4 underrepresented) were differentially abundant in serum from preeclamptic pregnancies compared with serum from normal pregnancies. Therefore, maternal serum miRNA assessment at first-trimester of pregnancy does not appear to have any predictive value for early preeclampsia.

Subject

Hipertensió en l'embaràs, Micro RNAs

Subject (English)

Hypertension in pregnancy, MicroRNAs

Citation

Collections

Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

LUQUE GÓMEZ, Ana, et al. Usefulness of circulating microRNAs for the prediction of early preeclampsia at first-trimester of pregnancy. Scientific Reports. 2014. Vol. 4. ISSN 2045-2322. [consulted: 12 of June of 2026]. Available at: https://hdl.handle.net/2445/125922

Export metadata

JSON - METS

Share record