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2014-05-08

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cc-by (c) Luque Gómez, Ana et al., 2014
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/125922

Usefulness of circulating microRNAs for the prediction of early preeclampsia at first-trimester of pregnancy

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https://doi.org/10.1038/srep04882

Resum

To assess the usefulness of circulating microRNAs (miRNAs) as non-invasive molecular biomarkers for early prediction of preeclampsia, a differential miRNA profiling analysis was performed in first-trimester pooled sera from 31 early preeclampsia patients, requiring delivery before 34 weeks of gestation, and 44 uncomplicated pregnancies using microfluidic arrays. Among a total of 754 miRNAs analyzed, the presence of 63 miRNAs (8%) was consistently documented in the sera from preeclampsia and control samples. Nevertheless, only 15 amplified miRNAs (2%) seemed to be differentially, although modestly, represented (fold change range: 0.4-1.4). After stem loop RT-qPCR from individual samples, the statistical analysis confirmed that none of the most consistent and differentially represented miRNAs (3 overrepresented and 4 underrepresented) were differentially abundant in serum from preeclamptic pregnancies compared with serum from normal pregnancies. Therefore, maternal serum miRNA assessment at first-trimester of pregnancy does not appear to have any predictive value for early preeclampsia.

Matèries

Hipertensió en l'embaràs, Micro RNAs

Matèries (anglès)

Hypertension in pregnancy, MicroRNAs

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Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

LUQUE GÓMEZ, Ana, FARWATI, Abduljalil, CROVETTO, Francesca, CRISPI BRILLAS, Fàtima, FIGUERAS RETUERTA, Francesc, GRATACÓS SOLSONA, Eduard, ARAN PERRAMON, Josep m.. Usefulness of circulating microRNAs for the prediction of early preeclampsia at first-trimester of pregnancy. _Scientific Reports_. 2014. Vol. 4. [consulta: 28 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/125922]

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