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Intestinal and hepatic nitrogen balance in the rat after the administration of an oral protein load
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The fate of a small oral dose of protein given to overnight-starved rats was studied. After 3 h, 62 per cent of the protein amino acids had been absorbed. Most of the absorbed N went into the bloodstream through the portal in the form of amino acids, but urea and ammonia were also present. About one-quarter of all absorbed N was carried as lymph amino acids. The liver was able to take all portal free ammonia and a large proportion of portal amino acids, releasing urea. The hepatic N balance was negative, indicating active proteolysis and net loss of liver protein.
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FERNÁNDEZ LÓPEZ, José Antonio, et al. Intestinal and hepatic nitrogen balance in the rat after the administration of an oral protein load. British Journal of Nutrition. 1993. Vol. 69, num. 733-742. ISSN 0007-1145. [consulted: 6 of June of 2026]. Available at: https://hdl.handle.net/2445/22127