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cc-by-nc-nd (c) Romero-Carrete, C.J. et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/224057

Predictors of long-term survival in patients with a first episode of acute heart failure

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Introduction: Acute heart failure (AHF) represents a critical event in heart failure progression, but data on long-term outcomes after first hospitalization remain scarce. The aim is to describe long-term survival and evaluate its predictors after the first episode of AHF. Material and methods: Patients from five Spanish hospitals with a confirmed first diagnosis of AHF were categorized based on survival (≥5 or <5 years). Thirteen independent variables were identified. Mortality was assessed using Kaplan-Meier curves after up to 10 years of follow-up. Adjusted odds ratios (OR) with 95% confidence intervals (CI) for mortality were calculated. Additionally, adjusted survival probabilities according to patient age and left ventricular ejection fraction (LVEF) were obtained using restricted cubic splines. Results: A total of 1986 patients were included, with a median age 76 years (range: 68-82), 50% women, and 57% with preserved LVEF. Five-year mortality was 52%. Adjusted analysis showed that age (OR, 0.470 per 10-year increment; 95% CI, 0.421-0.525), New York Heart Association class III-IV vs. I (OR, 0.476; 95% CI, 0.341-0.666) and II vs. I (OR, 0.780; 95% CI, 0.627-0.969), chronic kidney disease (OR, 0.609; 95% CI, 0.452-0.820), coronary artery disease (OR, 0.657; 95% CI, 0.523-0.824), diabetes mellitus (OR, 0.658; 95% CI, 0.534-0.811), and male sex (OR, 0.774; 95% CI, 0.625-0.958) were associated with death within 5 years. LVEF at inclusion was not related to 5-year survival. Conclusions: Survival after a first AHF episode is poor, with age, New York Heart Association class, kidney function, coronary artery disease, diabetes, and sex being key predictors of long-term mortality.

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Mortalitat, Factors de risc en les malalties, Insuficiència cardíaca, Persones grans

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Mortality, Risk factors in diseases, Heart failure, Older people

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Articles publicats en revistes (Física Quàntica i Astrofísica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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REPULLO, Daniel, FUENTES, Lidia, ANAYA BUSTOS, Sara, MIÑANA, Gemma, LLORENS SORIANO, Pere, MIRÓ I ANDREU, Òscar, ROMERO-CARRETE, Carlos jose, ALQUÉZAR ARBÉ, Aitor, NUÑEZ, Julio, GIL ESPINOSA, Victor, JACOB, Javier, AGUIRRE, Alfons, VILLAREJO JIMENEZ, Ana, BORJA-CANO, Maria, DE LA ESPRIELLA, Rafael, SANTAS, Enrique, SÁNCHEZ MARCOS, Carolina. Predictors of long-term survival in patients with a first episode of acute heart failure. _Kardiologia Polska_. 2025. Vol. 83, núm. 9, pàgs. 1020-1026. [consulta: 24 de novembre de 2025]. ISSN: 0022-9032. [Disponible a: https://hdl.handle.net/2445/224057]

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