Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/216956
Shared vulnerability and sex-dependent polygenic burden in psychotic disorders
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
Evidence suggests a remarkable shared genetic susceptibility between psychiatric disorders. However, sex-dependent differences have been less studied. We explored the contribution of schizophrenia (SCZ), bipolar disorder (BD) and major depressive disorder (MDD) polygenic scores (PGSs) on the risk for psychotic disorders and whether sex-dependent differences exist (CIBERSAM sample: 1826 patients and 1372 controls). All PGSs were significantly associated with psychosis. Sex-stratified analyses showed that the variance explained in psychotic disorders risk was significantly higher in males than in females for all PGSs. Our results confirm the shared genetic architecture across psychotic disorders and demonstrate sex-dependent differences in the vulnerability to psychotic disorders.
Subject (English)
Citation
Citation
MITJANS NIUBÓ, Marina, et al. Shared vulnerability and sex-dependent polygenic burden in psychotic disorders. European Neuropsychopharmacology. 2024. Vol. 86, num. 49-54. ISSN 0924-977X. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/216956