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Shared vulnerability and sex-dependent polygenic burden in psychotic disorders

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dc.contributor.authorMitjans Niubó, Marina
dc.contributor.authorPapiol, Sergi
dc.contributor.authorFatjó-Vilas Mestre, Mar
dc.contributor.authorGonzález-Peñas, Javier
dc.contributor.authorAcosta-Díez, Miriam
dc.contributor.authorZafrilla-López, Marina 
dc.contributor.authorCostas, Javier
dc.contributor.authorArango López, Celso
dc.contributor.authorVilella, Elisabet
dc.contributor.authorMartorell, Lourdes
dc.contributor.authorMoltó, M. Dolors
dc.contributor.authorBobes García, Julio
dc.contributor.authorCrespo-Facorro, Benedicto
dc.contributor.authorGonzález-Pinto, Ana
dc.contributor.authorFañanás Saura, Lourdes
dc.contributor.authorRosa de la Cruz, Araceli
dc.contributor.authorArias Sampériz, Bárbara
dc.date.accessioned2024-12-05T15:50:05Z
dc.date.available2024-12-05T15:50:05Z
dc.date.issued2024-09-01
dc.date.updated2024-12-05T15:50:05Z
dc.description.abstractEvidence suggests a remarkable shared genetic susceptibility between psychiatric disorders. However, sex-dependent differences have been less studied. We explored the contribution of schizophrenia (SCZ), bipolar disorder (BD) and major depressive disorder (MDD) polygenic scores (PGSs) on the risk for psychotic disorders and whether sex-dependent differences exist (CIBERSAM sample: 1826 patients and 1372 controls). All PGSs were significantly associated with psychosis. Sex-stratified analyses showed that the variance explained in psychotic disorders risk was significantly higher in males than in females for all PGSs. Our results confirm the shared genetic architecture across psychotic disorders and demonstrate sex-dependent differences in the vulnerability to psychotic disorders.   
dc.format.extent6 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec750527
dc.identifier.issn0924-977X
dc.identifier.urihttps://hdl.handle.net/2445/216956
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.euroneuro.2024.04.017
dc.relation.ispartofEuropean Neuropsychopharmacology, 2024, vol. 86, p. 49-54
dc.relation.urihttps://doi.org/10.1016/j.euroneuro.2024.04.017
dc.rightscc-by-nc-nd (c) Mitjans Niubó, Marina et al., 2024
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceArticles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
dc.subject.classificationEsquizofrènia
dc.subject.classificationTrastorn bipolar
dc.subject.classificationDepressió psíquica
dc.subject.classificationDiferències entre sexes (Psicologia)
dc.subject.otherSchizophrenia
dc.subject.otherManic-depressive illness
dc.subject.otherMental depression
dc.subject.otherSex differences (Psychology)
dc.titleShared vulnerability and sex-dependent polygenic burden in psychotic disorders
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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