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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/44092
Task-induced deactivation from rest extends beyond the default mode brain network
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Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized"default-mode network" (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes.
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HARRISON, Ben j., PUJOL NUEZ, Jesús, CONTRERAS RODRÍGUEZ, Oren, SORIANO MAS, Carles, LÓPEZ-SOLÀ, Marina, DEUS YELA, Juan, ORTIZ, Hector, BLANCO HINOJO, Laura, ALONSO ORTEGA, María del pino, HERNÁNDEZ RIBAS, Rosa, CARDONER, N. (narcís), MENCHÓN MAGRIÑÁ, José manuel. Task-induced deactivation from rest extends beyond the default mode brain network. _PLoS One_. 2011. Vol. 6, núm. 7, pàgs. e22964. [consulta: 21 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/44092]