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2014-07-05

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cc-by (c) Martin Loeches, Ignacio et al., 2014
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/121710

Predicting treatment failure in patients with community acquired pneumonia: a case-control study

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https://doi.org/10.1186/1465-9921-15-75

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INTRODUCTION: Treatment failure in community-acquired-pneumonia (CAP) patients is associated with a high mortality rate, and therefore are a matter of great concern in clinical management. Those patients have increased mortality and are a target population for randomized clinical trials. METHODS: A case-control study was performed in patients with CAP (non-failure cases vs. failure cases, discriminating by late and early failure). CRP, PCT, interleukin 1, 6, 8 and 10 and TNF were determined at days 1 and 3 of hospitalization. RESULTS: A total of 253 patients were included in this study where 83 patients presented treatment failure. Of these, 40 (48.2%) had early failure. A discriminative effect was found for a higher CURB-65 score among late failure patients (p = 0.004). A significant increase on day 1 of hospitalization in CRP (p < 0.001), PCT (p = 0.004), IL-6 (p < 0.001) and IL-8 (p = 0.02), and a decrease in IL-1 (p = 0.06) in patients with failure was observed compared with patients without failure. On day 3, only the increase in CRP (p < 0.001), PCT (p = 0.007) and IL-6 (p < 0.001) remained significant. Independent predictors for early failure were higher IL-6 levels on day 1 (OR = 1.78, IC = 1.2-2.6) and pleural effusion (OR = 2.25, IC = 1.0-5.3), and for late failure, higher PCT levels on day 3 (OR = 1.60, IC = 1.0-2.5), CURB-65 score ≥ 3 (OR = 1.43, IC = 1.0-2.0), and multilobar involvement (OR = 4.50, IC = 2.1-9.9). CONCLUSIONS: There was a good correlation of IL-6 levels and CAP failure and IL-6 & PCT with late CAP failure. Pleural effusion and multilobar involvement were simple clinical predictors of early and late failure, respectively.

Matèries

Pneumònia adquirida a la comunitat, Citoquines, Pneumònia

Matèries (anglès)

Community-acquired pneumonia, Cytokines, Pneumonia

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

MARTÍN LOECHES, Ignacio, VALLES, Xavier, MENÉNDEZ, Rosario, SIBILA VIDAL, Oriol, MONTULL, Beatriz, CILLÓNIZ, Catia, ARTIGAS, Antonio, TORRES MARTÍ, Antoni. Predicting treatment failure in patients with community acquired pneumonia: a case-control study. _Respiratory Research_. 2014. Vol. 15, núm. 75. [consulta: 8 de gener de 2026]. ISSN: 1465-993X. [Disponible a: https://hdl.handle.net/2445/121710]

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