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s41598-022-07185-5.pdf (3.4 MB)

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2022-02-24

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cc by (c) Gonzalez Diaz, Aida et al, 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/184448

Comparative pangenome analysis of capsulated Haemophilus influenzae serotype f highlights their high genomic stability

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https://doi.org/10.1038/s41598-022-07185-5

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Haemophilus influenzae is an opportunistic pathogen adapted to the human respiratory tract. Non-typeable H. influenzae are highly heterogeneous, but few studies have analysed the genomic variability of capsulated strains. This study aims to examine the genetic diversity of 37 serotype f isolates from the Netherlands, Portugal, and Spain, and to compare all capsulated genomes available on public databases. Serotype f isolates belonged to CC124 and shared few single nucleotide polymorphisms (SNPs) (n = 10,999), but a high core genome (> 80%). Three main clades were identified by the presence of 75, 60 and 41 exclusive genes for each clade, respectively. Multi-locus sequence type analysis of all capsulated genomes revealed a reduced number of clonal complexes associated with each serotype. Pangenome analysis showed a large pool of genes (n = 6360), many of which were accessory genome (n = 5323). Phylogenetic analysis revealed that serotypes a, b, and f had greater diversity. The total number of SNPs in serotype f was significantly lower than in serotypes a, b, and e (p < 0.0001), indicating low variability within the serotype f clonal complexes. Capsulated H. influenzae are genetically homogeneous, with few lineages in each serotype. Serotype f has high genetic stability regardless of time and country of isolation.

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Bacils, Genòmica

Matèries (anglès)

Bacillus (Bacteria), Genomics

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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GONZÁLEZ DÍAZ, Aida, CARRERA SALINAS, Anna, PINTO, Miguel, CUBERO, Meritxell, ENDE, Arie van der, LANGEREIS, Jeroen d., DOMÍNGUEZ, M. ángeles, ARDANUY, Carmen, BAJANCA LAVADO, Paula, MARTI, Sara. Comparative pangenome analysis of capsulated Haemophilus influenzae serotype f highlights their high genomic stability. _Scientific Reports_. 2022. Vol.  vol 12, núm. num 1. [consulta: 8 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/184448]

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