Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

654435.pdf (6.78 MB)

Document type

Article

Version

Published version

Publication date

2016

All rights reserved

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/161943

Age at first episode modulates diagnosis-related structurals brain abnormalities in patients with first-episode psychosis.

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1093/schbul/sbv128

Abstract

Brain volume and thickness abnormalities have been reported in first-episode psychosis (FEP). However, it is unclear if and how they are modulated by brain developmental stage (and, therefore, by age at FEP as a proxy). This is a multicenter cross-sectional case-control brain magnetic resonance imaging (MRI) study. Patients with FEP (n = 196), 65.3% males, with a wide age at FEP span (12-35 y), and healthy controls (HC) (n = 157), matched for age, sex, and handedness, were scanned at 6 sites. Gray matter volume and thickness measurements were generated for several brain regions using FreeSurfer software. The nonlinear relationship between age at scan (a proxy for age at FEP in patients) and volume and thickness measurements was explored in patients with schizophrenia spectrum disorders (SSD), affective psychoses (AFP), and HC. Earlier SSD cases (ie, FEP before 15-20 y) showed significant volume and thickness deficits in frontal lobe, volume deficits in temporal lobe, and volume enlargements in ventricular system and basal ganglia. First-episode AFP patients had smaller cingulate cortex volume and thicker temporal cortex only at early age at FEP (before 18-20 y). The AFP group also had age-constant (12-35-y age span) volume enlargements in the frontal and parietal lobe. Our study suggests that age at first episode modulates the structural brain abnormalities found in FEP patients in a nonlinear and diagnosis-dependent manner. Future MRI studies should take these results into account when interpreting samples with different ages at onset and diagnosis.

Subject

Psicosi, Cervell, Malformacions

Subject (English)

Psychoses, Brain, Human abnormalities

Citation

Collections

Articles publicats en revistes (Medicina)

Citation

PINA CAMACHO, Laura, et al. Age at first episode modulates diagnosis-related structurals brain abnormalities in patients with first-episode psychosis. Schizophrenia Bulletin. 2016. Vol. 42, num. 2, pags. 344-357. ISSN 0586-7614. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/161943

Export metadata

JSON - METS

Share record