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Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood term X-rays computed tomography contrast agents
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X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that requires intravenously administration of contrast agents to enhance the sensitivity and visualization of soft tissues. In this work, we have developed a novel CT contrast agent based on ternary Ag-Au-Se chalcogenide nanoparticles. A facile and gentle ligand exchange by using a 3 kDa PEGylated ligand with a dithiol dihydrolipoic as an anchor resulted in highly water-soluble and monodisperse nanoparticles. Moreover, the injected PEGylated ternary NPs presented excellent characteristics as a CT contrast agent with high bioavailability, low cytotoxicity and long blood circulation times with slow uptake by the mononuclear phagocyte system, thus being ideal for in vivo imaging.
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CARO, Carlos, DALMASES SOLÉ, Mariona, FIGUEROLA I SILVESTRE, Albert, GARCÍA-MARTÍN, M.l., PERNIA LEAL, Manuel. Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood term X-rays computed tomography contrast agents. _Nanoscale_. 2017. Vol. 9, núm. 21, pàgs. 7242-7251. [consulta: 24 de gener de 2026]. ISSN: 2040-3364. [Disponible a: https://hdl.handle.net/2445/154912]