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Accepted version

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2017-04-25

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/154912

Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood term X-rays computed tomography contrast agents

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https://doi.org/10.1039/C7NR01110E

Abstract

X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that requires intravenously administration of contrast agents to enhance the sensitivity and visualization of soft tissues. In this work, we have developed a novel CT contrast agent based on ternary Ag-Au-Se chalcogenide nanoparticles. A facile and gentle ligand exchange by using a 3 kDa PEGylated ligand with a dithiol dihydrolipoic as an anchor resulted in highly water-soluble and monodisperse nanoparticles. Moreover, the injected PEGylated ternary NPs presented excellent characteristics as a CT contrast agent with high bioavailability, low cytotoxicity and long blood circulation times with slow uptake by the mononuclear phagocyte system, thus being ideal for in vivo imaging.

Subject

Lligands, Nanopartícules, Tomografia

Subject (English)

Ligands, Nanoparticles, Tomography

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Articles publicats en revistes (Química Inorgànica i Orgànica)

Citation

CARO, Carlos, et al. Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood term X-rays computed tomography contrast agents. Nanoscale. 2017. Vol. 9, num. 21, pags. 7242-7251. ISSN 2040-3364. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/154912

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