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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/163519
Light-induced regulation of ligand-gated channel activity
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The control of ligand-gated receptors with light using photochromic compounds has evolved from the first handcrafted examples to accurate, engineered receptors, whose development is supported by rational design, high-resolution protein structures, comparative pharmacology and molecular biology manipulations. Photoswitchable regulators have been designed and characterized for a large number of ligand-gated receptors in the mammalian nervous system, including nicotinic acetylcholine, glutamate and GABA receptors. They provide a well-equipped toolbox to investigate synaptic and neuronal circuits in all-optical experiments. This focused review discusses the design and properties of these photoswitches, their applications and shortcomings and future perspectives in the field.
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BREGESTOVSKI, Piotr, MALEEVA, Galyna and GOROSTIZA LANGA, Pablo Ignacio. Light-induced regulation of ligand-gated channel activity. British Journal of Pharmacology. 2018. Vol. 175, num. 11, pags. 1892-1902. ISSN 0007-1188. [consulted: 16 of October of 2026]. Available at: https://hdl.handle.net/2445/163519