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Light-induced regulation of ligand-gated channel activity
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The control of ligand-gated receptors with light using photochromic compounds has evolved from the first handcrafted examples to accurate, engineered receptors, whose development is supported by rational design, high-resolution protein structures, comparative pharmacology and molecular biology manipulations. Photoswitchable regulators have been designed and characterized for a large number of ligand-gated receptors in the mammalian nervous system, including nicotinic acetylcholine, glutamate and GABA receptors. They provide a well-equipped toolbox to investigate synaptic and neuronal circuits in all-optical experiments. This focused review discusses the design and properties of these photoswitches, their applications and shortcomings and future perspectives in the field.
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BREGESTOVSKI, Piotr, MALEEVA, Galyna, GOROSTIZA LANGA, Pablo ignacio. Light-induced regulation of ligand-gated channel activity. _British Journal of Pharmacology_. 2018. Vol. 175, núm. 11, pàgs. 1892-1902. [consulta: 24 de gener de 2026]. ISSN: 0007-1188. [Disponible a: https://hdl.handle.net/2445/163519]