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Prischich 2021 accepted ms.pdf (698.22 KB)

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Article

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Accepted version

Publication date

2021-02-15

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/183210

Adrenergic Modulation With Photochromic Ligands

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https://doi.org/10.1002/anie.202010553

Abstract

© 2020 Wiley-VCH GmbH Adrenoceptors are ubiquitous and mediate important autonomic functions as well as modulating arousal, cognition, and pain on a central level. Understanding these physiological processes and their underlying neural circuits requires manipulating adrenergic neurotransmission with high spatio-temporal precision. Here we present a first generation of photochromic ligands (adrenoswitches) obtained via azologization of a class of cyclic amidines related to the known ligand clonidine. Their pharmacology, photochromism, bioavailability, and lack of toxicity allow for broad biological applications, as demonstrated by controlling locomotion in zebrafish and pupillary responses in mice.

Subject

Neurotransmissors, Receptors adrenèrgics

Subject (English)

Neurotransmitters, Adrenaline receptors

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Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Publicacions de projectes de recerca finançats per la UE

Citation

PRISCHICH, Davia, et al. Adrenergic Modulation With Photochromic Ligands. Angewandte Chemie. 2021. Vol.  vol 60, num. num 7, pags. 3625-3631. ISSN 1521-3773. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/183210

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