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235828.pdf (2.47 MB)

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2021-02-22

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cc-by-nc-nd (c) Sociedad Española de Psiquiatría y Sociedad Española de Psiquiatría Biológica, 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/220147

Effectiveness of enhancing cognitive reserve in children, adolescents and young adults at genetic risk for psychosis: study protocol for a randomized controlled trial

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Recurs relacionat

https://doi.org/10.1016/j.rpsm.2021.02.003

Resum

Background: Offspring of patients diagnosed with bipolar disorder and schizophrenia (Off-BDSZ) have a high genetic risk of developing a mental illness. The aim of this project is to develop and investigate the efficacy of an intervention aimed at this population, based on the concept of cognitive reserve. Methods: This is a multicenter randomized trial with an experimental test-retest design study with control group. Two groups will be included: a community comparison group (CC) and a Off-BDSZ group. A total of 108 Off-BDSZ and 65 CC aged between 6 and 25 years will be recruited. Off-BDSZ participants will be randomized to receive either Cognitive Reserve EnhAncement ThErapy (CREATE) (n=54), or a supportive approach (n=54). The CC group will be assessed at baseline. The duration of the intervention will be 3 months, with 12 weekly group sessions. The primary outcome will be the improvement in CR measured according to change in the Cognitive Reserve Assessment Scale in Health (CRASH) and Cognitive Reserve scale for Adolescents (CORE-A). All participants will be blindly evaluated using clinical, cognitive and neuroimaging measures at baseline, at three months (after the psychological intervention), and at twelve-month follow-up after treatment completion. Discussion: The results will provide insight into whether the CREATE-Offspring version may enhance cognitive reserve (CR) in child, adolescent and young adult Off-BDSZ as well as advance knowledge about changes in clinical manifestations, neuropsychological performance and brain structure and function associated with improving CR. This novel and cost-effective intervention represents an advance in the framework of preventive interventions in mental health.

Matèries

Esquizofrènia, Genètica, Trastorn bipolar, Cognició, Malalties mentals

Matèries (anglès)

Schizophrenia, Genetics, Manic-depressive illness, Cognition, Mental illness

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Articles publicats en revistes (Medicina)

Citació

SERNA, Elena de la, et al. Effectiveness of enhancing cognitive reserve in children, adolescents and young adults at genetic risk for psychosis: study protocol for a randomized controlled trial. Revista de Psiquiatria y Salud Mental. 2021. Vol. 16, num. 3, pags. 184-191. ISSN 1888-9891. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/220147

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