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2017-08-21

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cc-by (c) Gómez Acebo, Inés et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/127967

Risk model for prostate cancer using environmental and genetic factors in the spanish multi-case-control (MCC) study

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Recurs relacionat

https://doi.org/10.1038/s41598-017-09386-9

Resum

Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. 818 PCa cases and 1,006 healthy controls were compared. Subjects were interviewed on major lifestyle factors and family history. Fifty-six PCa susceptibility SNPs were genotyped. Risk models based on logistic regression were developed to combine environmental factors, family history and a genetic risk score. In the whole model, compared with subjects with low risk (reference category, decile 1), those carrying an intermediate risk (decile 5) had a 265% increase in PCa risk (OR = 3.65, 95% CI 2.26 to 5.91). The genetic risk score had an area under the ROC curve (AUROC) of 0.66 (95% CI 0.63 to 0.68). When adding the environmental score and family history to the genetic risk score, the AUROC increased by 0.05, reaching 0.71 (95% CI 0.69 to 0.74). Genetic susceptibility has a stronger risk value of the prediction that modifiable risk factors. While the added value of each SNP is small, the combination of 56 SNPs adds to the predictive ability of the risk model.

Matèries

Càncer de pròstata, Espanya, Homes, Genètica, Medi ambient, Factors de risc en les malalties

Matèries (anglès)

Prostate cancer, Spain, Men, Genetics, Natural environment, Risk factors in diseases

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (ISGlobal)

Citació

GÓMEZ ACEBO, Inés, DIERSSEN SOTOS, Trinidad, FERNÁNDEZ NAVARRO, Pablo, PALAZUELOS-CALDERÓN, Camilo, MORENO AGUADO, Víctor, ARAGONÈS SANZ, Núria, CASTAÑO-VINYALS, Gemma, JIMÉNEZ MOLEÓN, José juan, RUIZ CERDÁ, José l., PÉREZ GÓMEZ, Beatriz, RUIZ-DOMINGUEZ, José manuel, ALONSO-MOLERO, Jéssica, POLLÁN, Marina, KOGEVINAS, Manolis, LLORCA DÍAZ, Javier. Risk model for prostate cancer using environmental and genetic factors in the spanish multi-case-control (MCC) study. _Scientific Reports_. 2017. Vol. 7, núm. 8994. [consulta: 24 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/127967]

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