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2020-03-20

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cc-by (c) Teixeira, Maria de Céu et al., 2020
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/170072

Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)

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https://doi.org/10.3390/nano10030560

Abstract

Microbial infections are still among the major public health concerns since several yeasts and fungi, and other pathogenic microorganisms, are responsible for continuous growth of infections and drug resistance against bacteria. Antimicrobial resistance rate is fostering the need to develop new strategies against drug-resistant superbugs. Antimicrobial peptides (AMPs) are small peptide-based molecules of 5-100 amino acids in length, with potent and broad-spectrum antimicrobial properties. They are part of the innate immune system, which can represent a minimal risk of resistance development. These characteristics contribute to the description of these molecules as promising new molecules in the development of new antimicrobial drugs. However, efforts in developing new medicines have not resulted in any decrease of drug resistance yet. Thus, a technological approach on improving existing drugs is gaining special interest. Nanomedicine provides easy access to innovative carriers, which ultimately enable the design and development of targeted delivery systems of the most efficient drugs with increased efficacy and reduced toxicity. Based on performance, successful experiments, and considerable market prospects, nanotechnology will undoubtedly lead a breakthrough in biomedical field also for infectious diseases, as there are several nanotechnological approaches that exhibit important roles in restoring antibiotic activity against resistant bacteria. Keywords: antimicrobial peptides, bacterial and virus infections, coronavirus, antimicrobial resistance, nanomaterials, nanomedicine

Subject

Pèptids, Malalties bacterianes, Malalties víriques, Agents antiinfecciosos, Coronavirus

Subject (English)

Peptides, Bacterial diseases, Virus diseases, Anti-infective agents, Coronaviruses

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Collections

Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))

Citation

TEIXEIRA, Maria de Céu, et al. Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs). Nanomaterials. 2020. Vol. 10, num. 3, pags. 560. ISSN 2079-4991. [consulted: 10 of August of 2026]. Available at: https://hdl.handle.net/2445/170072

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