Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/107936
Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients.
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
The low-grade inflammation observed in obesity has been associated with a high-fat diet, though this relation is not fully understood. Bacterial endotoxin, produced by gut microbiota, may be the linking factor. However, this has not been confirmed in obese patients. To study the relationship between a high-fat diet and bacterial endotoxin, we analyzed postprandial endotoxemia in morbidly obese patients after a fat overload. The endotoxin levels were determined in serum and the chylomicron fraction at baseline and 3 h after a fat overload in 40 morbidly obese patients and their levels related with the degree of insulin resistance and postprandial hypertriglyceridemia. The morbidly obese patients with the highest postprandial hypertriglyceridemia showed a significant increase in lipopolysaccharide (LPS) levels in serum and the chylomicron fraction after the fat overload. Postprandial chylomicron LPS levels correlated positively with the difference between postprandial triglycerides and baseline triglycerides. There were no significant correlations between C-reactive protein (CRP) and LPS levels. The main variables contributing to serum LPS levels after fat overload were baseline and postprandial triglyceride levels but not glucose or insulin resistance. Additionally, superoxide dismutase activity decreased significantly after the fat overload. Postprandial LPS increase after a fat overload is related to postprandial hypertriglyceridemia but not to degree of insulin resistance in morbidly obese patients.
Matèries (anglès)
Citació
Citació
CLEMENTE POSTIGO, M., QUEIPO ORTUÑO, María isabel, MURRI, M., BOTO ORDÓÑEZ, María, PÉREZ-MARTÍNEZ, Pablo, ANDRÉS LACUEVA, Ma. cristina, CARDONA, Fernando, TINAHONES, Francisco j.. Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients.. _Journal of Lipid Research_. 2012. Vol. 53, núm. 5, pàgs. 973-978. [consulta: 25 de gener de 2026]. ISSN: 0022-2275. [Disponible a: https://hdl.handle.net/2445/107936]