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2022-08-23

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cc-by (c) Garufi, Giovanna et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/194391

Updated Neoadjuvant Treatment Landscape for Early Triple Negative Breast Cancer: Immunotherapy, Potential Predictive Biomarkers, and Novel Agents

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Recurs relacionat

https://doi.org/10.3390/cancers14174064

Resum

Triple-negative breast cancer (TNBC) is characterized by the absence of hormone receptor and HER2 expression, and therefore a lack of therapeutic targets. Anthracyclines and taxane-based neoadjuvant chemotherapy have historically been the cornerstone of treatment of early TNBC. However, genomic and transcriptomic analyses have suggested that TNBCs include various subtypes, characterized by peculiar genomic drivers and potential therapeutic targets. Therefore, several efforts have been made to expand the therapeutic landscape of early TNBC, leading to the introduction of platinum and immunomodulatory agents into the neoadjuvant setting. This review provides a comprehensive overview of the currently available evidence regarding platinum agents and immune-checkpoint-inhibitors for the neoadjuvant treatment of TNBC, as well as the novel target therapies that are currently being evaluated in this setting. Taking into account the economic issues and the side effects of the expanding therapeutic options, we focus on the potential efficacy biomarkers of the emerging therapies, in order to select the best therapeutic strategy for each specific patient.

Matèries

Càncer de mama, Inhibidors enzimàtics, Tractament adjuvant del càncer, Immunitat cel·lular, Marcadors bioquímics

Matèries (anglès)

Breast cancer, Enzyme inhibitors, Adjuvant treatment of cancer, Cellular immunity, Biochemical markers

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Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

GARUFI, Giovanna, CARBOGNIN, Luisa, SCHETTINI, Francesco, SEGUÍ, Elia, DI LEONE, Alba, FRANCO, Antonio, PARIS, Ida, SCAMBIA, Giovanni, TORTORA, Giampaolo, FABI, Alessandra. Updated Neoadjuvant Treatment Landscape for Early Triple Negative Breast Cancer: Immunotherapy, Potential Predictive Biomarkers, and Novel Agents. _Cancers_. 2022. Vol. 14, núm. 17, pàgs. 4064. [consulta: 30 de gener de 2026]. ISSN: 2072-6694. [Disponible a: https://hdl.handle.net/2445/194391]

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