Dijous 11 de juny, el Dipòsit Digital no estarà operatiu de 15:00 a 17:00 h per tasques de manteniment. Disculpeu les molèsties.
El jueves 11 de Junio, el Dipòsit Digital no estará operativo de 15:00 a 17:00 h debido a tareas de mantenimiento. Disculpen las molestias.
Thursday, Jun 11th, the Digital Repository will be unavailable due to a system update.

Files

676874.pdf (1.14 MB)

Document type

Article

Version

Published version

Publication date

2017-09-01

Publication license

cc-by (c) Llinàs-Arias, Pere et al., 2017
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/130098

Epigenetic inactivation of tumour suppressor coding and non-coding genes in human cancer: an update

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1098/rsob.170152

Abstract

Cancer cells undergo many different alterations during their transformation, including genetic and epigenetic events. The controlled division of healthy cells can be impaired through the downregulation of tumour suppressor genes. Here, we provide an update of the mechanisms in which epigenetically altered coding and non-coding tumour suppressor genes are implicated. We will highlight the importance of epigenetics in the different molecular pathways that lead to enhanced and unlimited capacity of division, genomic instability, metabolic shift, acquisition of mesenchymal features that lead to metastasis, and tumour plasticity. We will briefly describe these pathways, focusing especially on genes whose epigenetic inactivation through DNA methylation has been recently described, as well as on those that are well established as being epigenetically silenced in cancer. A brief perspective of current clinical therapeutic approaches that can revert epigenetic inactivation of non-coding tumour suppressor genes will also be given.

Subject

Cèl·lules canceroses, Metilació, Epigènesi, Proteïnes supressores de tumors, Efectes secundaris dels medicaments

Subject (English)

Cancer cells, Methylation, Epigenesis, Tumor suppressor protein, Drug side effects

Citation

Collections

Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

LLINÀS-ARIAS, Pere and ESTELLER, Manel. Epigenetic inactivation of tumour suppressor coding and non-coding genes in human cancer: an update. Open Biology. 2017. Vol. 7, num. 9, pags. rsob. ISSN 2046-2441. [consulted: 10 of June of 2026]. Available at: https://hdl.handle.net/2445/130098

Export metadata

JSON - METS

Share record