Miniatura

Fitxers

662497.pdf (6.81 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2013-12-18

Llicència de publicació

cc-by-nc-nd (c) Prat Aparicio, Aleix et al., 2013
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/99123

Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

http://dx.doi.org/10.1038/srep03544

Resum

To improve our understanding of the biological relationships among different types of cancer, we have characterized variation in gene expression patterns in a set of 1,707 samples representing 6 human cancer types (breast, ovarian, brain, colorectal, lung adenocarcinoma and squamous cell lung cancer). In the unified dataset, breast tumors of the Basal-like subtype were found to represent a unique molecular entity as any other cancer type, including the rest of breast tumors, while showing striking similarities with squamous cell lung cancers. Moreover, gene signatures tracking various cancer- and stromal-related biological processes such as proliferation, hypoxia and immune activation were found expressed similarly in different proportions of tumors across the various cancer types. These data suggest that clinical trials focusing on tumors with common profiles and/or biomarker expression rather than their tissue of origin are warranted with a special focus on Basal-like breast cancer and squamous cell lung carcinoma.

Matèries

Genòmica, Càncer, Marcadors bioquímics, Assaigs clínics, Oncologia

Matèries (anglès)

Genomics, Cancer, Biochemical markers, Clinical trials, Oncology

Citació

Col·leccions

Articles publicats en revistes (Medicina)

Citació

PRAT APARICIO, Aleix, ADAMO, Barbara, FAN, Cheng, PEG, Vicente, VIDAL LOSADA, Maria jesús, GALVÁN, Patricia, VIVANCOS, Ana, NUCIFORO, Paolo, PALMER, Héctor g., DAWOOD, Shaheenah, RODÓN, Jordi, RAMÓN Y CAJAL AGÜERAS, Santiago, CAMPO, Josep maria, FELIP, Enriqueta, TABERNERO CATURLA, Josep, CORTÉS, Javier. Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity. _Scientific Reports_. 2013. Vol. 3, núm. 3544. [consulta: 25 de febrer de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/99123]

Exportar metadades

JSON - METS

Compartir registre