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2019-10-07

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cc by (c) Garcia Moure et al., 2019
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/169750

The oncolytic adenovirus VCN-01 promotes anti-tumor effect in primitive neuroectodermal tumor models

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https://doi.org/10.1038/s41598-019-51014-1

Abstract

Last advances in the treatment of pediatric tumors has led to an increase of survival rates of children affected by primitive neuroectodermal tumors, however, still a significant amount of the patients do not overcome the disease. In addition, the survivors might suffer from severe side effects caused by the current standard treatments. Oncolytic virotherapy has emerged in the last years as a promising alternative for the treatment of solid tumors. In this work, we study the anti-tumor effect mediated by the oncolytic adenovirus VCN-01 in CNS-PNET models. VCN-01 is able to infect and replicate in PNET cell cultures, leading to a cytotoxicity and immunogenic cell death. In vivo, VCN-01 increased significantly the median survival of mice and led to long-term survivors in two orthotopic models of PNETs. In summary, these results underscore the therapeutic effect ofVCN-01 for rare pediatric cancers such as PNETs, and warrants further exploration on the use of this virus to treat them.

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Oncologia pediàtrica, Adenovirus

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Tumors in children, Adenoviruses

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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GARCIA MOURE, Marc, et al. The oncolytic adenovirus VCN-01 promotes anti-tumor effect in primitive neuroectodermal tumor models. Scientific Reports. 2019. Vol. 9, num. 14368. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/169750

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