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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/169750
The oncolytic adenovirus VCN-01 promotes anti-tumor effect in primitive neuroectodermal tumor models
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Last advances in the treatment of pediatric tumors has led to an increase of survival rates of children affected by primitive neuroectodermal tumors, however, still a significant amount of the patients do not overcome the disease. In addition, the survivors might suffer from severe side effects caused by the current standard treatments. Oncolytic virotherapy has emerged in the last years as a promising alternative for the treatment of solid tumors. In this work, we study the anti-tumor effect mediated by the oncolytic adenovirus VCN-01 in CNS-PNET models. VCN-01 is able to infect and replicate in PNET cell cultures, leading to a cytotoxicity and immunogenic cell death. In vivo, VCN-01 increased significantly the median survival of mice and led to long-term survivors in two orthotopic models of PNETs. In summary, these results underscore the therapeutic effect ofVCN-01 for rare pediatric cancers such as PNETs, and warrants further exploration on the use of this virus to treat them.
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GARCIA MOURE, Marc, MARTÍNEZ VÉLEZ, Naiara, GONZÁLEZ HUARRIZ, Marisol, MARRODÁN, Lucía, CASCALLÒ, Manel, ALEMANY BONASTRE, Ramon, PATIÑO GARCÍA, Ana, ALONSO, Marta m.. The oncolytic adenovirus VCN-01 promotes anti-tumor effect in primitive neuroectodermal tumor models. _Scientific Reports_. 2019. Vol. 9, núm. 14368. [consulta: 24 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/169750]