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2020-01-01

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cc by (c) Bassetti et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/173255

Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts

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https://doi.org/10.1186/s13054-020-2793-y

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Background: Almost one third of the patients with candidemia develop septic shock. The understanding why some patients do and others do not develop septic shock is very limited. The objective of this study was to identify variables associated with septic shock development in a large population of patients with candidemia. Methods: A post hoc analysis was performed on two prospective, multicenter cohort of patients with candidemia from 12 hospitals in Spain and Italy. All episodes occurring from September 2016 to February 2018 were analyzed to assess variables associated with septic shock development defined according to The Third International Consensus Definition for Sepsis and Septic Shock (Sepsis-3). Results: Of 317 candidemic patients, 99 (31.2%) presented septic shock attributable to candidemia. Multivariate logistic regression analysis identifies the following factors associated with septic shock development: age > 50 years (OR 2.57, 95% CI 1.03–6.41, p = 0.04), abdominal source of the infection (OR 2.18, 95% CI 1.04–4.55, p = 0.04), and admission to a general ward at the time of candidemia onset (OR 0.21, 95% CI, 0.12–0.44, p = 0.001). Septic shock development was independently associated with a greater risk of 30-day mortality (OR 2.14, 95% CI 1.08–4.24, p = 0.02). Conclusions: Age and abdominal source of the infection are the most important factors significantly associated with the development of septic shock in patients with candidemia. Our findings suggest that host factors and source of the infection may be more important for development of septic shock than intrinsic virulence factors of organisms.

Matèries

Candidiasi, Xoc sèptic

Matèries (anglès)

Candidiasis, Septic shock

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

BASSETTI, Matteo, VENA, Antonio, MEROI, Marco, CARDOZO ESPINOLA, Celia, CUERVO REQUENA, Guillermo, GIACOBBE, Daniele roberto, SALAVERT, Miguel, MERINO, Paloma, GIOIA, Francesca, FERNÁNDEZ RUIZ, Mario, LÓPEZ CORTÉS, Luis eduardo, ALMIRANTE, Benito, ESCOLÀ VERGÉ, Laura, MONTEJO, Miguel, AGUILAR GUISADO, Manuela, PUERTA-ALCALDE, Pedro, TASIAS, Mariona, RUIZ GAITÁN, Alba, GONZÁLEZ, Fernando, PUIG ASENSIO, Mireia, MARCO REVERTÉ, Francesc, PEMÁN, Javier, FORTÚN, Jesús, AGUADO, José maría, SORIANO VILADOMIU, Alex, CARRATALÀ, Jordi, GARCIA VIDAL, Carolina, VALERIO, Maricela, SARTOR, Assunta, BOUZA, Emilio, MUÑOZ, Patricia. Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts. _Critical Care_. 2020. Vol. 24. [consulta: 29 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/173255]

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