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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/100940
The Genotype of the Donor for the (GT)n Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation
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The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect. Short alleles (≤(GT)15) for the (GT)n polymorphism in the promoter/enhancer of FOXP3 are associated with a higher expression of FOXP3, and hypothetically with an increase of regulatory T cell activity. This polymorphism has been related to the development of auto- or alloimmune conditions including type 1 diabetes or graft rejection in renal transplant recipients. However, its impact in the allo-transplant setting has not been analyzed. In the present study, which includes 252 myeloablative HLA-identical allo-transplants, multivariate analysis revealed a lower incidence of grade III-IV acute graft versus host disease (GVHD) in patients transplanted from donors harboring short alleles (OR = 0.26, CI 0.08-0.82, p = 0.021); without affecting chronic GVHD or graft versus leukemia effect, since cumulative incidence of relapse, event free survival and overall survival rates are similar in both groups of patients.
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NORIEGA, Victor, MARTÍNEZ-LAPERCHE, Carolina, BUCES, Elena, PION, Marjorie, SÁNCHEZ-HERNÁNDEZ, Noemí, MARTÍN-ANTONIO, Beatriz, GUILLEM, Vicent, BOSCH-VIZCAYA, Anna, BENTO, Leyre, GONZÁLEZ RIVERA, Milagros, BALSALOBRE, Pascual, KWON, Mi, SERRANO, David, GAYOSO, Jorge, CÁMARA, Rafael de la, BRUNET, Salut, ROJAS-CONTRERAS, Rafael, NIETO, José b., MARTÍNEZ, Carmen, GÓNZALEZ, Marcos, ESPIGADO, Ildefonso, VALLEJO, Carlos, SAMPOL, Antonia, JIMÉNEZ-VELASCO, Antonio, URBANO ISPIZUA, Álvaro, SOLANO, Carlos, GALLARDO, David, DÍEZ-MARTÍN, José l., BUÑO, Ismael, Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH). The Genotype of the Donor for the (GT)n Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation. _PLoS One_. 2015. Vol. 10, núm. 10. [consulta: 23 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/100940]