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Doba_oC_Nat_Commun_2019.pdf (998.85 KB)

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2019-05-15

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cc by (c) Dobaño et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/134962

Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

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http://dx.doi.org/10.1038/s41467-019-10195-z

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RTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-repeat and C-terminal domains) after a 3-dose vaccination against time to clinical malaria events during 12-months. Here we report that RTS,S/AS01E induces substantial increases in IgG levels from pre- to post-vaccination (p\xE2\x80\x89<\xE2\x80\x890.001), higher in NANP than C-terminus (2855 vs 1297 proportional change between means), and higher concentrations and avidities in children than infants (p\xE2\x80\x89<\xE2\x80\x890.001). Baseline CSP IgG levels are elevated in malaria cases than controls (p\xE2\x80\x89<\xE2\x80\x890.001). Both, IgG magnitude to NANP (hazard ratio [95% confidence interval] 0.61 [0.48-0.76]) and avidity to C-terminus (0.07 [0.05-0.90]) post-vaccination are significantly associated with vaccine efficacy. IgG avidity to the C-terminus emerges as a significant contributor to RTS,S/AS01E-mediated protection.

Matèries

Vacuna de la malària, Infants, Africans

Matèries (anglès)

Malaria vaccine, Children

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Articles publicats en revistes (ISGlobal)

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DOBAÑO, Carlota, SANZ RÓDENAS, Héctor, SORGHO, Hermann, DOSOO, David, MPINA, Maximilian, UBILLOS, Itziar, AGUILAR, Ruth, FORD, Tom, DÍEZ-PADRISA, Núria, WILLIAMS, Nana aba, AYESTARAN, Aintzane, TRAORE, Ousmane, NHABOMBA, Augusto j., JAIROCE, Chenjerai tobias sixpence, WAITUMBI, John, AGNANDJI, Selidji todagbe, KARIUKI, Simon, ABDULLA, Salim, APONTE, John j., MORDMÜLLER, Benjamin, ASANTE, Kwaku poku, OWUSU-AGYEI, Seth, TINTO, Halidou, CAMPO, Joseph j., MONCUNILL PIÑAS, Gemma, GYAN, Ben, VALIM, Clarissa, DAUBENBERGER, Claudia. Concentration and avidity of antibodies to different
                circumsporozoite epitopes correlate with RTS,S/AS01E malaria
                vaccine efficacy. _Nature Communications_. 2019. Vol. 10. [consulta: 9 de gener de 2026]. ISSN: 2041-1723. [Disponible a: https://hdl.handle.net/2445/134962]

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