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Doba_oC_Nat_Commun_2019.pdf (998.85 KB)

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2019-05-15

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cc by (c) Dobaño et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/134962

Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

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Recurs relacionat

http://dx.doi.org/10.1038/s41467-019-10195-z

Resum

RTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-repeat and C-terminal domains) after a 3-dose vaccination against time to clinical malaria events during 12-months. Here we report that RTS,S/AS01E induces substantial increases in IgG levels from pre- to post-vaccination (p\xE2\x80\x89<\xE2\x80\x890.001), higher in NANP than C-terminus (2855 vs 1297 proportional change between means), and higher concentrations and avidities in children than infants (p\xE2\x80\x89<\xE2\x80\x890.001). Baseline CSP IgG levels are elevated in malaria cases than controls (p\xE2\x80\x89<\xE2\x80\x890.001). Both, IgG magnitude to NANP (hazard ratio [95% confidence interval] 0.61 [0.48-0.76]) and avidity to C-terminus (0.07 [0.05-0.90]) post-vaccination are significantly associated with vaccine efficacy. IgG avidity to the C-terminus emerges as a significant contributor to RTS,S/AS01E-mediated protection.

Matèries

Vacuna de la malària, Infants, Africans

Matèries (anglès)

Malaria vaccine, Children

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Articles publicats en revistes (ISGlobal)

Citació

DOBAÑO, Carlota, et al. Concentration and avidity of antibodies to different
                circumsporozoite epitopes correlate with RTS,S/AS01E malaria
                vaccine efficacy. Nature Communications. 2019. Vol. 10. ISSN 2041-1723. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/134962

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