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Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy
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RTS,S/AS01E has been tested in a phase 3 malaria vaccine
study with partial efficacy in African children and infants. In
a cohort of 1028 subjects from one low (Bagomoyo) and two high
(Nanoro, Kintampo) malaria transmission sites, we analysed IgG
plasma/serum concentration and avidity to CSP (NANP-repeat and
C-terminal domains) after a 3-dose vaccination against time to
clinical malaria events during 12-months. Here we report that
RTS,S/AS01E induces substantial increases in IgG levels from
pre- to post-vaccination (p\xE2\x80\x89<\xE2\x80\x890.001),
higher in NANP than C-terminus (2855 vs 1297 proportional change
between means), and higher concentrations and avidities in
children than infants (p\xE2\x80\x89<\xE2\x80\x890.001).
Baseline CSP IgG levels are elevated in malaria cases than
controls (p\xE2\x80\x89<\xE2\x80\x890.001). Both, IgG
magnitude to NANP (hazard ratio [95% confidence interval] 0.61
[0.48-0.76]) and avidity to C-terminus (0.07 [0.05-0.90])
post-vaccination are significantly associated with vaccine
efficacy. IgG avidity to the C-terminus emerges as a significant
contributor to RTS,S/AS01E-mediated protection.
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DOBAÑO, Carlota, et al. Concentration and avidity of antibodies to different
circumsporozoite epitopes correlate with RTS,S/AS01E malaria
vaccine efficacy. Nature Communications. 2019. Vol. 10. ISSN 2041-1723. [consulta: 12 de maig de 2026]. Disponible a: https://hdl.handle.net/2445/134962