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2021-05-01

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cc by-nc-nd (c) Remuzgo Martínez, Sara et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/179746

HLA association with the susceptibility to anti-synthetase syndrome

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https://doi.org/10.1016/j.jbspin.2020.105115

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Objective: To investigate the human leukocyte antigen (HLA) association with anti-synthetase syndrome (ASSD). Methods: We conducted the largest immunogenetic HLA-DRB1 and HLA-B study to date in a homogeneous cohort of 168 Caucasian patients with ASSD and 486 ethnically matched healthy controls by sequencing-based-typing. Results: A statistically significant increase of HLA-DRB1*03:01 and HLA-B*08:01 alleles in patients with ASSD compared to healthy controls was disclosed (26.2% versus 12.2%, P=1.56E-09, odds ratio-OR [95% confidence interval-CI]=2.54 [1.84-3.50] and 21.4% versus 5.5%, P=18.95E-18, OR [95% CI]=4.73 [3.18-7.05]; respectively). Additionally, HLA-DRB1*07:01 allele was significantly decreased in patients with ASSD compared to controls (9.2% versus 17.5%, P=0.0003, OR [95% CI]=0.48 [0.31-0.72]). Moreover, a statistically significant increase of HLA-DRB1*03:01 allele in anti-Jo-1 positive compared to anti-Jo-1 negative patients with ASSD was observed (31.8% versus 15.5%, P=0.001, OR [95% CI]=2.54 [1.39-4.81]). Similar findings were observed when HLA carrier frequencies were assessed. The HLA-DRB1*03:01 association with anti-Jo-1 was unrelated to smoking history. No HLA differences in patients with ASSD stratified according to the presence/absence of the most representative non-anti-Jo-1 anti-synthetase autoantibodies (anti-PL-12 and anti-PL-7), arthritis, myositis or interstitial lung disease were observed. Conclusions: Our results support the association of the HLA complex with the susceptibility to ASSD.

Matèries

Malalties autoimmunitàries, Autoanticossos, Malalties hereditàries

Matèries (anglès)

Autoimmune diseases, Genetic diseases, Autoantibodies

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

REMUZGO MARTÍNEZ, Sara, ATIENZA MATEO, Belén, OCEJO VINYALS, J. gonzalo, PULITO CUETO, Verónica, PRIETO PEÑA, Diana, GENRE, Fernanda, MARQUEZ, Ana, LLORCA, Javier, MORA CUESTA, Víctor m., ITURBE FERNÁNDEZ, David, RIESCO, Laura, ORTEGO CENTENO, Norberto, PÉREZ GÓMEZ, Nair, MERA, Antonio, MARTÍNEZ BARRIO, Julia, LÓPEZ LONGO, Francisco javier, LERA GÓMEZ, Leticia, MORIANO, Clara, DÍEZ, Elvira, TOMERO, Eva, CALVO ALÉN, Jaime, ROMERO BUENO, Fredeswinda, SANCHEZ PERNAUTE, Olga, NUÑO-NUÑO, Laura, BONILLA, Gema, GRAFIA, Ignacio, PRIETO GONZÁLEZ, Sergio, NARVÁEZ GARCÍA, Francisco javier, TRALLERO ARAGUAS, Ernesto, SELVA O’CALLAGHAN, Albert, GUALILLO, Oreste, MARTÍN, Javier, CAVAGNA, Lorenzo, CASTAÑEDA, Santos, CIFRIAN, José m., RENZONI, Elisabetta a., LÓPEZ MEJÍAS, Raquel, GONZÁLEZ GAY, Miguel a.. HLA association with the susceptibility to anti-synthetase syndrome. _Joint Bone Spine_. 2021. Vol. 88, núm. 3, pàgs. 105115. [consulta: 23 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/179746]

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