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Toda_H_Nat_Commun_2020.pdf (2.48 MB)

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2020

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cc by (c) Toda, Haruka et al, 2020
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/182976

Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence.

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http://dx.doi.org/ 10.1038/s41467-020-16337-y

Abstract

Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals. Moreover, this uptake induces specific upregulation of ICAM-1 associated with the translocation of NF-kB to the nucleus. After this uptake, P. vivax-infected reticulocytes obtained from patients show specific adhesion properties to hSFs, reversed by inhibiting NF-kB translocation to the nucleus. Together, these data provide physiological EV-based insights into the mechanisms of human malaria pathology and support the existence of P. vivax-adherent parasite subpopulations in the microvasculature of the human spleen.

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Malària, Relacions hoste-paràsit

Subject (English)

Malaria, Host-parasite relationships

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Articles publicats en revistes (ISGlobal)
Publicacions de projectes de recerca finançats per la UE

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TODA, Haruka, et al. Plasma-derived extracellular vesicles from Plasmodium vivax
                patients signal spleen fibroblasts via NF-kB facilitating
                parasite cytoadherence. Nature Communications. 2020. Vol.  vol 11. ISSN 2041-1723. [consulted: 9 of June of 2026]. Available at: https://hdl.handle.net/2445/182976

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