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Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence.
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Plasmodium vivax is the most widely distributed human
malaria parasite. Previous studies have shown that circulating
microparticles during P. vivax acute attacks are indirectly
associated with severity. Extracellular vesicles (EVs) are
therefore major components of circulating plasma holding
insights into pathological processes. Here, we demonstrate that
plasma-derived EVs from Plasmodium vivax patients (PvEVs) are
preferentially uptaken by human spleen fibroblasts (hSFs) as
compared to the uptake of EVs from healthy individuals.
Moreover, this uptake induces specific upregulation of ICAM-1
associated with the translocation of NF-kB to the nucleus. After
this uptake, P. vivax-infected reticulocytes obtained from
patients show specific adhesion properties to hSFs, reversed by
inhibiting NF-kB translocation to the nucleus. Together, these
data provide physiological EV-based insights into the mechanisms
of human malaria pathology and support the existence of P.
vivax-adherent parasite subpopulations in the microvasculature
of the human spleen.
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TODA, Haruka, et al. Plasma-derived extracellular vesicles from Plasmodium vivax
patients signal spleen fibroblasts via NF-kB facilitating
parasite cytoadherence. Nature Communications. 2020. Vol. vol 11. ISSN 2041-1723. [consulta: 11 de maig de 2026]. Disponible a: https://hdl.handle.net/2445/182976