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Toda_H_Nat_Commun_2020.pdf (2.48 MB)

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2020

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cc by (c) Toda, Haruka et al, 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/182976

Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence.

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Recurs relacionat

http://dx.doi.org/ 10.1038/s41467-020-16337-y

Resum

Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals. Moreover, this uptake induces specific upregulation of ICAM-1 associated with the translocation of NF-kB to the nucleus. After this uptake, P. vivax-infected reticulocytes obtained from patients show specific adhesion properties to hSFs, reversed by inhibiting NF-kB translocation to the nucleus. Together, these data provide physiological EV-based insights into the mechanisms of human malaria pathology and support the existence of P. vivax-adherent parasite subpopulations in the microvasculature of the human spleen.

Matèries

Malària, Relacions hoste-paràsit

Matèries (anglès)

Malaria, Host-parasite relationships

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Articles publicats en revistes (ISGlobal)
<b>Publicacions de projectes de recerca finançats per la UE</b>

Citació

TODA, Haruka, DÍAZ VARELA, Míriam, SEGUÍ BARBER, Joan, ROOBSOONG, Wanlapa, BARO, Barbara, GARCIA SILVA, Susana, GALIANO, Alicia, GUALDRÓN LÓPEZ, Melisa, ALMEIDA, Anne cristine gomes, BRITO, Marcelo a. m., CARDOSO DE MELO, Gisely, APARICI HERRAIZ, Iris, CASTRO CAVADÍA, Carlos, MONTEIRO, Wuelton marcelo, BORRÀS, Eva, SABIDÓ AGUADÉ, Eduard, ALMEIDA, Igor correia de, CHOJNACKI, Jakub, MARTÍNEZ PICADO, Francisco javier, CALVO, Maria, ARMENGOL, Maria del pilar, CARMONA FONSECA, Jaime, YASNOT, María fernanda, LAUZURICA, Ricardo, MARCILLA, Antonio, PEINADO, Hector, GALINSKI, Mary r., LACERDA, Marcus v. g., SATTABONGKOT, Jetsumon, FERNÁNDEZ BECERRA, Carmen, PORTILLO OBANDO, Hernando a. del. Plasma-derived extracellular vesicles from Plasmodium vivax
                patients signal spleen fibroblasts via NF-kB facilitating
                parasite cytoadherence.. _Nature Communications_. 2020. Vol.  vol 11. [consulta: 25 de febrer de 2026]. ISSN: 2041-1723. [Disponible a: https://hdl.handle.net/2445/182976]

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