Lactobacillus fermentum CECT5716 Supplementation in Rats During Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and Microbiota

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dc.contributor.authorAzagra Boronat, Ignasi
dc.contributor.authorTres Oliver, Alba
dc.contributor.authorMassot Cladera, Malen
dc.contributor.authorFranch i Masferrer, Àngels
dc.contributor.authorCastell, Margarida
dc.contributor.authorGuardiola Ibarz, Francesc
dc.contributor.authorPérez-Cano, Francisco J.
dc.contributor.authorRodríguez Lagunas, María José
dc.date.accessioned2020-05-14T08:14:52Z
dc.date.available2020-05-14T08:14:52Z
dc.date.issued2020-02-28
dc.date.updated2020-05-14T08:14:52Z
dc.description.abstractProbiotics have shown potential for their use in early life. This study aimed to investigate whether the administration of Lactobacillus fermentum CECT5716 during pregnancy and lactation periods impacts maternal and offspring plasma lipid profile, immune system and microbiota. Rats were supplemented with the probiotic during gestation and two weeks of lactation. After supplementation, although the microbiota composition was not affected, the probiotic strain was detected in all cecal contents of dams and in some of their pups. Dams showed reduced proportion of T cytotoxic cells in the mesenteric lymph nodes, modulation of intestinal cytokines (IL-10 and IL-12) and changes in plasma fatty acids (20:0, 22:0, 20:5 n-3, and 18:3 n-6). Pups showed changes in immunoglobulins (intestinal IgA and plasmatic IgG2a and IgG2c) and fatty acid profile (17:0, 22:0, and 18:2 n-6). Overall, Lactobacillus fermentum CECT5716 supplementation contributed to beneficially modulating the immune system of the mother and its offspring.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec699558
dc.identifier.issn2073-4409
dc.identifier.pmid32121244
dc.identifier.urihttps://hdl.handle.net/2445/160177
dc.language.isoeng
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/cells9030575
dc.relation.ispartofCells, 2020, vol. 9, num. 3, p. 575
dc.relation.urihttps://doi.org/10.3390/cells9030575
dc.rightscc-by (c) Azagra Boronat, Ignasi et al., 2020
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Bioquímica i Fisiologia)
dc.subject.classificationEmbaràs
dc.subject.classificationProbiòtics
dc.subject.classificationAlletament
dc.subject.classificationRosegadors
dc.subject.classificationÀcids grassos
dc.subject.classificationMicrobiota
dc.subject.otherPregnancy
dc.subject.otherProbiotics
dc.subject.otherBreastfeeding
dc.subject.otherRodents
dc.subject.otherFatty acids
dc.subject.otherMicrobiota
dc.titleLactobacillus fermentum CECT5716 Supplementation in Rats During Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and Microbiota
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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Articles publicats en revistes (Bioquímica i Fisiologia)
Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)