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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/223420
Estudio de las secuelas a largo plazo de los traumatismos craneoencefálicos (TCE): evaluación de la memoria declarativa y procedimental y de su sustrato neuroanatómico
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[spa] Introducción y objectivos. Los estudios realizados hasta la actualidad permiten considerar el hipocampo y el estriado como el sustrato neural de las memorias declarativa y procedimental, respectivamente. Si bien ambas estructuras son vulnerables al traumatismo craneoencefálico, y diversos estudios han observado que tanto la memoria declarativa como la procedimental también decaen a consecuencia de traumatismo craneoencefálico, los estudios volumétricos realizados hasta ahora no muestran evidencia de la relación entre la atrofia de ambas estructuras y el grado de alteración de la memoria. El presente estudio se centra en investigar el grado de alteración de las memorias declarativa y procedimental en niños que, de pequeños, sufrieron traumatismo craneoencefálico de moderado a grave.
Pacientes y métodos Diecinueve pacientes y sus respectivos controles fueron evaluados en tareas de memoria declarativa y aprendizaje motor. Los resultados mostraron que los sujetos con traumatismo craneoencefálico exhibían un peor rendimiento en ambas tareas. Además, para relacionar el rendimiento neuropsicológico con los datos volumétricos del hipocampo y el estriado, se realizaron análisis de correlaciones.
Resultados Se encontraron correlaciones positivas entre el volumen del hipocampo y la memoria para objetos del test ‘objeto-localización’. Por su parte, el volumen del estriado correlacionaba positivamente con el aprendizaje motor y la memoria verbal.
Conclusión Los resultados obtenidos sugieren que los mecanismos de plasticidad no compensan completamente los déficit de memoria resultantes de la pérdida neural en el cerebro immaduro.
[eng] Summary. Introduction and objectives. The hippocampus and the striatum have been proposed as respectively cerebral substrates of declarative and procedural memory. Both structures are vulnerable to traumatic brain injury. Although declarative and procedural memory have been reported to be impaired in traumatic brain injury (TBI), volumetric measures have so far failed to associate this impairment with atrophy of hippocampal and striatal structures. In our study, we investigated the profile of declarative and procedural memory in children who suffered from moderate to severe traumatic brain injury during childhood (injury-test interval: 9.42±1.98 years). Patients and methods. Nineteen patients and matched controls were evaluated on tests of declarative memory and motor learning. Results showed that TBI subjects exhibit poorer performance in both tasks. Moreover, structural magnetic resonance images were obtained from TBI subjects. In order to relate neuropsychological performance with hippocampal and neostriatal volumetric data, correlation analyses were performed. Results. Significant positive correlations were obtained between hippocampal volume and memory for objects. Striatal volume correlated positively with motor learning and with verbal memory. Conclusions. It thus seems that plasticity does not completely compensate for the memory deficits resultant from neural loss in the immature brain.
[eng] Summary. Introduction and objectives. The hippocampus and the striatum have been proposed as respectively cerebral substrates of declarative and procedural memory. Both structures are vulnerable to traumatic brain injury. Although declarative and procedural memory have been reported to be impaired in traumatic brain injury (TBI), volumetric measures have so far failed to associate this impairment with atrophy of hippocampal and striatal structures. In our study, we investigated the profile of declarative and procedural memory in children who suffered from moderate to severe traumatic brain injury during childhood (injury-test interval: 9.42±1.98 years). Patients and methods. Nineteen patients and matched controls were evaluated on tests of declarative memory and motor learning. Results showed that TBI subjects exhibit poorer performance in both tasks. Moreover, structural magnetic resonance images were obtained from TBI subjects. In order to relate neuropsychological performance with hippocampal and neostriatal volumetric data, correlation analyses were performed. Results. Significant positive correlations were obtained between hippocampal volume and memory for objects. Striatal volume correlated positively with motor learning and with verbal memory. Conclusions. It thus seems that plasticity does not completely compensate for the memory deficits resultant from neural loss in the immature brain.
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VERGER MAESTRE, Katia, SERRA Y GRABULOSA, Josep ma., JUNQUÉ I PLAJA, Carme, ÁLVAREZ AMADOR, Alfredo, BARTRÉS FAZ, David, MERCADER SOBREQUÉS, José ma.. Estudio de las secuelas a largo plazo de los traumatismos craneoencefálicos (TCE): evaluación de la memoria declarativa y procedimental y de su sustrato neuroanatómico. _Revista de Neurologia_. 2001. Vol. 33, núm. 1, pàgs. 30-34. [consulta: 2 de gener de 2026]. ISSN: 0210-0010. [Disponible a: https://hdl.handle.net/2445/223420]