Files

699623.pdf (472.47 KB)

Document type

Article

Version

Published version

Publication date

2008-03-13

All rights reserved

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/176325

Epigenetics in Cancer

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1056/NEJMra072067

Abstract

Classic genetics alone cannot explain the diversity of phenotypes within a population. Nor does classic genetics explain how, despite their identical DNA sequences, monozygotic twins or cloned animals can have different phenotypes and different susceptibilities to a disease. The concept of epigenetics offers a partial explanation of these phenomena. First introduced by C.H. Waddington in 1939 to name "the causal interactions between genes and their products, which bring the phenotype into being," epigenetics was later defined as heritable changes in gene expression that are not due to any alteration in the DNA sequence.

Subject

ADN, Epigènesi, Expressió gènica, Proteïnes supressores de tumors, Fisiologia

Subject (English)

DNA, Epigenesis, Gene expression, Tumor suppressor protein, Physiology

Citation

Collections

Articles publicats en revistes (Ciències Fisiològiques)

Citation

ESTELLER, Manel. Epigenetics in Cancer. New England Journal of Medicine. 2008. Vol. 358, num. 11, pags. 1148-1159. ISSN 0028-4793. [consulted: 16 of June of 2026]. Available at: https://hdl.handle.net/2445/176325

Export metadata

JSON - METS

Share record