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Epigenetics in Cancer

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dc.contributor.authorEsteller, Manel, 1968-
dc.date.accessioned2021-04-15T10:35:56Z
dc.date.available2021-04-15T10:35:56Z
dc.date.issued2008-03-13
dc.date.updated2021-04-15T10:35:57Z
dc.description.abstractClassic genetics alone cannot explain the diversity of phenotypes within a population. Nor does classic genetics explain how, despite their identical DNA sequences, monozygotic twins or cloned animals can have different phenotypes and different susceptibilities to a disease. The concept of epigenetics offers a partial explanation of these phenomena. First introduced by C.H. Waddington in 1939 to name "the causal interactions between genes and their products, which bring the phenotype into being," epigenetics was later defined as heritable changes in gene expression that are not due to any alteration in the DNA sequence.
dc.format.extent12 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec699623
dc.identifier.issn0028-4793
dc.identifier.pmid18337604
dc.identifier.urihttps://hdl.handle.net/2445/176325
dc.language.isoeng
dc.publisherMassachusetts Medical Society
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1056/NEJMra072067
dc.relation.ispartofNew England Journal of Medicine, 2008, vol. 358, num. 11, p. 1148-1159
dc.relation.urihttps://doi.org/10.1056/NEJMra072067
dc.rights(c) Massachusetts Medical Society, 2008
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Ciències Fisiològiques)
dc.subject.classificationADN
dc.subject.classificationEpigènesi
dc.subject.classificationExpressió gènica
dc.subject.classificationProteïnes supressores de tumors
dc.subject.classificationFisiologia
dc.subject.otherDNA
dc.subject.otherEpigenesis
dc.subject.otherGene expression
dc.subject.otherTumor suppressor protein
dc.subject.otherPhysiology
dc.titleEpigenetics in Cancer
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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