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Article

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Published version

Publication date

2010-07-06

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cc-by (c) Carreras et al., 2010
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/13645

Obstructive apneas induce early activation of mesenchymal stem cells and enhancement of endothelial wound healing

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http://dx.doi.org/10.1186/1465-9921-11-91

Abstract

Background: The aim was to test the hypothesis that the blood serum of rats subjected to recurrent airway obstructions mimicking obstructive sleep apnea (OSA) induces early activation of bone marrow-derived mesenchymal stem cells (MSC) and enhancement of endothelial wound healing. Methods: We studied 30 control rats and 30 rats subjected to recurrent obstructive apneas (60 per hour, lasting 15 s each, for 5 h). The migration induced in MSC by apneic serum was measured by transwell assays. MSC-endothelial adhesion induced by apneic serum was assessed by incubating fluorescent-labelled MSC on monolayers of cultured endothelial cells from rat aorta. A wound healing assay was used to investigate the effect of apneic serum on endothelial repair. Results: Apneic serum showed significant increase in chemotaxis in MSC when compared with control serum: the normalized chemotaxis indices were 2.20 +- 0.58 (m +- SE) and 1.00 +- 0.26, respectively (p < 0.05). MSC adhesion to endothelial cells was greater (1.75 +- 0.14 -fold; p < 0.01) in apneic serum than in control serum. When compared with control serum, apneic serum significantly increased endothelial wound healing (2.01 +- 0.24 -fold; p < 0.05). Conclusions: The early increases induced by recurrent obstructive apneas in MSC migration, adhesion and endothelial repair suggest that these mechanisms play a role in the physiological response to the challenges associated to OSA.

Subject

Trastorns respiratoris, Fisiologia animal

Subject (English)

Respiration disorders, Physiology, Comparative

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Articles publicats en revistes (Ciències Fisiològiques)

Citation

CARRERAS, Alba, et al. Obstructive apneas induce early activation of mesenchymal stem cells and enhancement of endothelial wound healing. Respiratory Research 2010. 11:91. Vol. 1-7. ISSN 1465-9921. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/13645

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