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Seroprevalence of CMV, HSV-2 and HBV among HIV-Infected Malawian Children: A Cross-sectional Survey
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BACKGROUND: Little is known about viral co-infections in African
human immunodeficiency virus (HIV)-infected children. We
examined the prevalence of seromarkers for cytomegalovirus
(CMV), herpes simplex virus type 2 (HSV-2) and hepatitis B virus
(HBV) infections among HIV-infected, antiretroviral treatment
(ART)-naive children in Lilongwe, Malawi. METHODS: Ninety-one
serum samples were tested for IgG and IgM antibodies to CMV, and
IgG antibodies to HSV-2 and hepatitis B surface antigen (HBsAg).
Baseline demographic, clinical and laboratory data were
abstracted from electronic records. RESULTS: CMV IgG was the
most common positive result in all age groups (in 73% of
children <1 year, and 100% in all other groups). Three
patients were CMV IgM positive (3.3%), suggesting acute
infection. HSV-2 IgG was positive in four patients (4.4%), and
HBsAg in two (2.2%). CONCLUSIONS: CMV infection occurred early
in life, and few children had specific signs of CMV infection at
the time of ART initiation. Unrecognized HBV infection
represents opportunities for testing and treatment of HIV/HBV
co-infected children.
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VARO, Rosauro, et al. Seroprevalence of CMV, HSV-2 and HBV among HIV-Infected Malawian
Children: A Cross-sectional Survey. Journal of Tropical Pediatrics. 2016. Vol. 0, num. 1-7. ISSN 0142-6338. [consulted: 5 of October of 2026]. Available at: https://hdl.handle.net/2445/98683