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2018-08

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/134069

Toxoplasmosis in transplant recipients, Europe, 2010-2014

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https://doi.org/10.3201/eid2408.180045

Abstract

Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe. We collected electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010-2014. Serologic pretransplant screening of allo-hematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. SOT recipients were systematically screened in 6 countries. Targeted anti-Toxoplasma chemoprophylaxis was heterogeneous. A total of 87 toxoplasmosis cases were recorded (58 allo-HSCTs, 29 SOTs). The 6-month survival rate was lower among Toxoplasma-seropositive recipients and among allo-hematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis remains associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management.

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Toxoplasma, Antibiòtics, Paràsits, Europa

Subject (English)

Toxoplasma, Antibiotics, Parasites, Europe

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

ROBERT-GANGNEUX, Florence, et al. Toxoplasmosis in transplant recipients, Europe, 2010-2014. Emerging Infectious Diseases. 2018. Vol. 24, num. 8, pags. 1497-1504. ISSN 1080-6040. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/134069

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