Fitxers

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2025-12

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cc-by (c) Pascual-Diaz, Saül et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/231377

Brain-immune biological correlates of quality of life in adolescents with chronic pain

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https://doi.org/10.1016/j.bbi.2025.106225

Resum

Chronic musculoskeletal (MSK) pain affects a substantial proportion of youth, with 5 % reporting high-impact symptoms. Chronic pain in youth leads to multifaceted negative consequences that profoundly affect adolescents’ quality of life (QoL) and future outcomes. Recent studies suggest that neuro-immune interactions significantly contribute to chronic pain. However, how systemic immune dysregulation influences brain function, and how these brain changes affect well-being and functioning in chronic pain remains unclear. This study aims to examine the convergence between immune function and brain processing during a multisensory task to identify novel mechanistic pathways that may explain reduced QoL in adolescents with chronic MSK pain (N = 129). We used a multisensory fMRI task designed to mimic the unpleasant sensory experiences that adolescents and adults with chronic pain often encounter in daily life. Higher task-evoked activation in the rostral anterior cingulate and dorsomedial prefrontal cortices (rACC–dmPFC), which support threat appraisal and response regulation, was associated with lower physical QoL (pFWE = 0.005). Lower physical QoL was also associated with augmented functional connectivity between the rACC-dmPFC region and sensory processing areas in the somatosensory (pFWE = 0.002) and visual (pFWE = 0.049) cortices. Higher systemic pro-inflammatory activity in immature neutrophils was also associated with lower physical QoL (p = 0.01). Furthermore, task-evoked brain activation in the rACC-dmPFC partially mediated the relationship between neutrophil-mediated inflammatory responses and reduced physical QoL. These findings suggest a potential neuro-immune pathway through which systemic immune alterations may affect brain function and QoL in adolescents with chronic MSK pain.

Matèries

Qualitat de vida, Trastorn bipolar en els adolescents

Matèries (anglès)

Quality of life, Manic-depressive illness in adolescence

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Articles publicats en revistes (Medicina)

Citació

SIMONS, Laura, et al. Brain-immune biological correlates of quality of life in adolescents with chronic pain. Brain. Behavior. Vol.  and Immunity - Health, num. 2025, pags. 132. [consulted: 26 of September of 2026]. Available at: https://hdl.handle.net/2445/231377

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