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2017-08-14

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cc by (c) Pastor et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/115803

IP-10 Levels as an Accurate Screening Tool to Detect Acute HIV Infection in Resource-Limited Settings

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http://dx.doi.org/10.1038/s41598-017-08218-0

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Acute HIV infection (AHI) is the period prior to seroconversion characterized by high viral replication, hyper-transmission potential and commonly, non-specific febrile illness. AHI detection requires HIV-RNA viral load (VL) determination, which has very limited access in low-income countries due to restrictive costs and implementation constraints. We sought to identify a biomarker that could enable AHI diagnosis in scarce-resource settings, and to evaluate the feasibility of its implementation. HIV-seronegative adults presenting at the Manhica District Hospital, Mozambique, with reported-fever were tested for VL. Plasma levels of 49 inflammatory biomarkers from AHI (n = 61) and non-HIV infected outpatients (n = 65) were determined by Luminex and ELISA. IP-10 demonstrated the best predictive power for AHI detection (AUC = 0.88 [95%CI 0.80-0.96]). A cut-off value of IP-10 >/= 161.6 pg/mL provided a sensitivity of 95.5% (95%CI 85.5-99.5) and a specificity of 76.5% (95%CI 62.5-87.2). The implementation of an IP-10 screening test could avert from 21 to 84 new infections and save from US$176,609 to US$533,467 to the health system per 1,000 tested patients. We conclude that IP-10 is an accurate biomarker to screen febrile HIV-seronegative individuals for subsequent AHI diagnosis with VL. Such an algorithm is a cost-effective strategy to prevent disease progression and a substantial number of further HIV infections.

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VIH (Virus), Cribratge

Matèries (anglès)

HIV (Viruses), Medical screening

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Articles publicats en revistes (ISGlobal)

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PASTOR, Lucía, CASELLAS, Aina, CARRILLO MOLINA, Jorge, ALONSO, Sergi, PARKER, Erica, FUENTE SORO, Laura, JAIROCE, Chenjerai tobias sixpence, MANDOMANDO, Inácio, BLANCO, Julià, NANICHE, Denise. IP-10 Levels as an Accurate Screening Tool to Detect Acute HIV
                Infection in Resource-Limited Settings. _Scientific Reports_. 2017. Vol. 7, núm. 1, pàgs. 8104. [consulta: 24 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/115803]

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