Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate

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dc.contributor.authorMaga, Giovanni
dc.contributor.authorRadi, Marco
dc.contributor.authorZanoli, Samantha
dc.contributor.authorManetti, Fabrizio
dc.contributor.authorCancio, Reynel
dc.contributor.authorHübscher, Ulrich
dc.contributor.authorSpadari, Silvio
dc.contributor.authorFalciani, Chiara
dc.contributor.authorTerrazas Martínez, Montserrat
dc.contributor.authorVilarrasa i Llorens, Jaume
dc.contributor.authorBotta, Maurizio
dc.date.accessioned2022-03-04T15:23:36Z
dc.date.available2022-03-04T15:23:36Z
dc.date.issued2007
dc.date.updated2022-03-04T15:23:37Z
dc.description.abstractHow odd! A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec713452
dc.identifier.issn1433-7851
dc.identifier.urihttps://hdl.handle.net/2445/183770
dc.language.isoeng
dc.publisherWiley-VCH
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1002/anie.200604165
dc.relation.ispartofAngewandte Chemie-International Edition, 2007, vol. 46, num. 11, p. 1810-1813
dc.relation.urihttps://doi.org/10.1002/anie.200604165
dc.rights(c) Wiley-VCH, 2007
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationNucleòsids
dc.subject.classificationPirimidines
dc.subject.classificationRadiocristal·lografia
dc.subject.otherNucleosides
dc.subject.otherPyrimidines
dc.subject.otherX-ray crystallography
dc.titleDiscovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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