Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

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dc.contributor.authorBerndt, Sonja I.
dc.contributor.authorCamp, Nicola J.
dc.contributor.authorSkibola, Christine F.
dc.contributor.authorVijai, Joseph
dc.contributor.authorWang, Zhaoming
dc.contributor.authorGu, Jian
dc.contributor.authorNieters, Alexandra
dc.contributor.authorKelly, Rachel S.
dc.contributor.authorSmedby, Karin E.
dc.contributor.authorMonnereau, Alain
dc.contributor.authorCozen, Wendy
dc.contributor.authorNorth, Kari E.
dc.contributor.authorLiang, Liming
dc.contributor.authorCox, Angela
dc.contributor.authorCrouch, Simon
dc.contributor.authorPark, Ju-Hyun
dc.contributor.authorChatterjee, Nilanjan
dc.contributor.authorZhang, Yawei
dc.contributor.authorSnowden, John A.
dc.contributor.authorWright, Josh
dc.contributor.authorFraumeni, Joseph F.
dc.contributor.authorMontalvan, Rebecca
dc.contributor.authorRothman, Nathaniel
dc.contributor.authorOffit, Kenneth
dc.contributor.authorCocco, Pierluigi
dc.contributor.authorSanjosé Llongueras, Silvia de
dc.contributor.authorCerhan, James R.
dc.contributor.authorChanock, Stephen J.
dc.contributor.authorNovak, Anne J.
dc.contributor.authorSlager, Susan L.
dc.contributor.authorLan, Qing
dc.contributor.authorTeras, Lauren R.
dc.contributor.authorBirmann, Brenda M.
dc.contributor.authorMachado, Moara
dc.contributor.authorShanafelt, Tait D.
dc.contributor.authorBrooks-Wilson, Angela R.
dc.contributor.authorHartge, Patricia
dc.contributor.authorPurdue, Mark P.
dc.contributor.authorChang, Ellen T.
dc.contributor.authorVajdic, Claire M.
dc.contributor.authorGiles, Graham G.
dc.contributor.authorZeleniuch-Jacquotte, Anne
dc.contributor.authorLawrence, Charles
dc.contributor.authorConde, Lucía
dc.contributor.authorBurdett, Laurie
dc.contributor.authorHutchinson, Amy
dc.contributor.authorYe, Yuanqing
dc.contributor.authorZhi, Degui
dc.contributor.authorAllmer, Cristine
dc.contributor.authorCall, Timothy G.
dc.contributor.authorWeiner, George J.
dc.contributor.authorKay, Neil E.
dc.contributor.authorLiebow, Mark
dc.contributor.authorCunningham, Julie M.
dc.contributor.authorSala Serra, Núria
dc.contributor.authorHjalgrim, Henrik
dc.contributor.authorAdami, Hans-Olov
dc.contributor.authorMelbye, Mads
dc.contributor.authorDiver, W. Ryan
dc.contributor.authorGlimelius, Bengt
dc.contributor.authorBenavente, Yolanda
dc.contributor.authorGlenn, Martha
dc.contributor.authorCurtin, Karen
dc.contributor.authorCannon-Albright, Lisa A.
dc.contributor.authorChaffee, Kari G.
dc.contributor.authorLink, Brian K.
dc.contributor.authorBracci, Paige M.
dc.contributor.authorRiby, Jacques
dc.contributor.authorArnett, Donna K.
dc.contributor.authorCaporaso, Neil E.
dc.contributor.authorLeach, Justin M.
dc.contributor.authorHolly, Elizabeth A.
dc.contributor.authorJackson, Rebecca D. J.
dc.contributor.authorSeverson, Richard K.
dc.contributor.authorBrennan, Paul
dc.contributor.authorTinker, Lesley F.
dc.contributor.authorWeinberg, J. Brice
dc.contributor.authorCasabonne, Delphine
dc.contributor.authorBecker, Nikolaus
dc.contributor.authorBoffetta, Paolo
dc.contributor.authorChirlaque, María Dolores
dc.contributor.authorForetova, Lenka
dc.contributor.authorMaynadié, Marc
dc.contributor.authorMcKay, James D.
dc.contributor.authorStrom, Sara S.
dc.contributor.authorStaines, Anthony
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorAchenbach, Sara J.
dc.contributor.authorVachon, Celine M.
dc.contributor.authorGoldin, Lynn R.
dc.contributor.authorZheng, Tongzhang
dc.contributor.authorLeis, Jose F.
dc.contributor.authorNorman, Aaron D.
dc.contributor.authorRoos, Anneclaire J. De
dc.contributor.authorMorton, Lindsay M.
dc.contributor.authorBertrand, Kimberly A.
dc.contributor.authorRiboli, Elio
dc.contributor.authorVineis, Paolo
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorTurner, Jenny
dc.contributor.authorMilne, Roger L.
dc.contributor.authorMasala, Giovanna
dc.contributor.authorConnors, Joseph M.
dc.contributor.authorVermeulen, Roel C. H.
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorSouthey, Melissa C.
dc.contributor.authorHuang, Jinyan
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorVirtamo, Jarmo
dc.contributor.authorWeinstein, Stephanie J.
dc.contributor.authorSpinelli, John J.
dc.contributor.authorClavel, Jacqueline
dc.contributor.authorMa, Baoshan
dc.contributor.authorHolford, Theodore R.
dc.contributor.authorVillano, Danylo J.
dc.contributor.authorMaria, Ann
dc.contributor.authorWu, Xifeng
dc.contributor.authorGascoyne, Randy D.
dc.contributor.authorGiovannucci, Edward L.
dc.contributor.authorKraft, Peter
dc.contributor.authorKricker, Anne
dc.contributor.authorWang, Sophia S.
dc.contributor.authorEnnas, Maria Grazia
dc.contributor.authorFerri, Giovanni M.
dc.contributor.authorMiligi, Lucia
dc.contributor.authorYeager, Meredith
dc.date.accessioned2018-12-11T10:47:25Z
dc.date.available2018-12-11T10:47:25Z
dc.date.issued2016-03-09
dc.date.updated2018-07-25T07:52:02Z
dc.description.abstractChronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P<5 x 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P = 7.19 x 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P = 2.12 x 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
dc.format.extent9 p.
dc.format.mimetypeapplication/pdf
dc.identifier.pmid26956414
dc.identifier.urihttps://hdl.handle.net/2445/126875
dc.language.isoeng
dc.publisherNature Publishing
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/ncomms10933
dc.relation.ispartofNature Communications, 2016, vol. 7
dc.relation.urihttps://doi.org/10.1038/ncomms10933
dc.rightscc by (c) Berndt et al., 2016
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationLeucèmia limfocítica crònica
dc.subject.classificationMalalties hereditàries
dc.subject.otherChronic lymphocytic leukemia
dc.subject.otherGenetic disorders
dc.titleMeta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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