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Childhood maltreatment interacts with hypothalamic pituitary adrenal axis negative feedback and major depression effects on cognitive performance.pdf (1.74 MB)

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Article

Data de publicació

2021-01-01

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cc by-nc (c) Salvat Pujol, Neus et al.; 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/176092

Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance

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Recurs relacionat

https://doi.org/10.1080/20008198.2020.1857955

Resum

Background: Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). Objectives: We aimed to assess the potential modulating effects of MDD diagnosis or HPA axis function in the association between different types of CM and cognitive performance in adulthood. Methods: Sixty-eight MDD patients and 87 healthy controls were recruited. CM was assessed with the Childhood Trauma Questionnaire. We obtained three latent variables for neuropsychological performance (verbal memory, visual memory and executive function/processing speed) after running a confirmatory factor analysis with cognitive tests applied. Dexamethasone suppression test ratio (DSTR) was performed using dexamethasone 0.25 mg. Results: Different types of CM had different effects on cognition, modulated by MDD diagnosis and HPA axis function. Individuals with physical maltreatment and MDD presented with enhanced cognition in certain domains. The DSTR differentially modulated the association between visual memory and physical neglect or sexual abuse. Conclusions: HPA axis-related neurobiological mechanisms leading to cognitive impairment might differ depending upon the type of CM. Our results suggest a need for early assessment and intervention on cognition and resilience mechanisms in individuals exposed to CM to minimize its deleterious and lasting effects.

Matèries

Maltractament infantil, Depressió psíquica, Trastorns cognitius

Matèries (anglès)

Child abuse, Cognition disorders, Mental depression

Citació

Col·leccions

Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

SALVAT PUJOL, Neus, LABAD, Javier, URRETAVIZCAYA SARACHAGA, Mikel, ARRIBA ARNAU, Aida de, SEGALÀS COSI, Cinto, REAL, Eva, FERRER, Alex, CRESPO, José m., JIMÉNEZ-MURCIA, Susana, SORIANO MAS, Carles, MENCHÓN MAGRIÑÁ, José manuel, SORIA, Virginia. Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance. _European Journal of Psychotraumatology_. 2021. Vol. 12, núm. 1, pàgs. 1857955. [consulta: 20 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/176092]

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