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Clin Infect Dis.-2016-Marks-627-33.pdf (335.29 KB)

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2016-05-23

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cc by (c) Marks et al., 2016
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/101569

Metaanalysis of the Performance of a Combined Treponemal and Nontreponemal Rapid Diagnostic Test for Syphilis and Yaws

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http://dx.doi.org/10.1093/cid/ciw348

Abstract

BACKGROUND: The human treponematoses are important causes of disease. Mother-to-child transmission of syphilis remains a major cause of stillbirth and neonatal death. There are also almost 100 000 cases of endemic treponemal disease reported annually, predominantly yaws. Rapid diagnostic tests (RDTs) would improve access to screening for these diseases. Most RDTs cannot distinguish current and previous infection. The Dual Path Platform (DPP) Syphilis Screen & Confirm test includes both a treponemal (T1) and nontreponemal (T2) component and may improve the accuracy of diagnosis. METHODS: We conducted a metaanalysis of published and unpublished evaluations of the DPP-RDT for the diagnosis of syphilis and yaws. We calculated the sensitivity, specificity, and overall agreement of the test compared with reference laboratory tests. RESULTS: Nine evaluations, including 7267 tests, were included. Sensitivity was higher in patients with higher titer rapid plasma reagin (>/=1:16) for both the T1 (98.2% vs 90.1%, P < .0001) and the T2 component (98.2% vs 80.6%, P < .0001). Overall agreement between the DPP test and reference serology was 85.2% (84.4%-86.1%). Agreement was highest for high-titer active infection and lowest for past infection. CONCLUSIONS: The RDT has good sensitivity and specificity of the treponemal and nontreponemal components both in cases of suspected syphilis and yaws, although the sensitivity is decreased at lower antibody titers.

Subject

Sífilis, Malalties de transmissió sexual

Subject (English)

Syphilis, Sexually transmitted diseases

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MARKS, Michael, et al. Metaanalysis of the Performance of a Combined Treponemal and
                Nontreponemal Rapid Diagnostic Test for Syphilis and Yaws. Clinical Infectious Diseases. 2016. Vol. 65, num. 5, pags. 627-633. ISSN 1058-4838. [consulted: 10 of August of 2026]. Available at: https://hdl.handle.net/2445/101569

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