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journal.pone.0257353.pdf (1.07 MB)

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2021-09-10

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cc by (c) González Rincón, Julia et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/182726

Genomic mutation profile in progressive chronic lymphocytic leukemia patients prior to first-line chemoimmunotherapy with FCR and rituximab maintenance (REM)

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https://doi.org/10.1371/journal.pone.0257353

Resum

Chronic Lymphocytic Leukemia (CLL) is the most prevalent leukemia in Western countries and is notable for its variable clinical course. This variability is partly reflected by the mutational status of IGHV genes. Many CLL samples have been studied in recent years by next-generation sequencing. These studies have identified recurrent somatic mutations in NOTCH1, SF3B1, ATM, TP53, BIRC3 and others genes that play roles in cell cycle, DNA repair, RNA metabolism and splicing. In this study, we have taken a deep-targeted massive sequencing approach to analyze the impact of mutations in the most frequently mutated genes in patients with CLL enrolled in the REM (rituximab en mantenimiento) clinical trial. The mutational status of our patients with CLL, except for the TP53 gene, does not seem to affect the good results obtained with maintenance therapy with rituximab after front-line FCR treatment.

Matèries

Leucèmia limfocítica crònica, Rituximab, Gene expression

Matèries (anglès)

Chronic lymphocytic leukemia, Rituximab, Expressió gènica

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

GONZÁLEZ RINCÓN, Julia, GARCIA VELA, José a., GÓMEZ, Sagrario, FERNÁNDEZ CUEVAS, Belén, NOVA GURUMETA, Sara, PÉREZ SANZ, Nuria, ALCOCEBA, Miguel, GONZÁLEZ, Marcos, ANGUITA, Eduardo, LÓPEZ JIMÉNEZ, Javier, GONZÁLEZ BARCA, Eva, YÁÑEZ, Lucrecia, PÉREZ PERSONA, Ernesto, SERNA, Javier de la, FERNÁNDEZ ZARZOSO, Miguel, DEBEN, Guillermo, PEÑALVER, Francisco j., FERNÁNDEZ, María c., PÉREZ DE OTEYZA, Jaime, ANDREU, M. ángeles, RUÍZ GUINALDO, M. ángeles, PAZ ARIAS, Raquel, GARCÍA MALO, Maria dolores, RECASENS, Valle, COLLADO, Rosa, CÓRDOBA, Raúl, NAVARRO MATILLA, Belén, SÁNCHEZ BEATO, Margarita, GARCÍA MARCO, José a.. Genomic mutation profile in progressive chronic lymphocytic leukemia patients prior to first-line chemoimmunotherapy with FCR and rituximab maintenance (REM). _PLOS ONE_. 2021. Vol. 16, núm. 9, pàgs. e0257353. [consulta: 29 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/182726]

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