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Synthesis and antitumor activity of mechercharmycin A analogues

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dc.contributor.authorHernández Romero, Delia
dc.contributor.authorAltuna, Marta
dc.contributor.authorCuevas, Carmen
dc.contributor.authorAligué i Alemany, Rosa Maria
dc.contributor.authorAlbericio Palomera, Fernando
dc.contributor.authorÁlvarez Domingo, Mercedes
dc.date.accessioned2014-07-18T11:58:36Z
dc.date.available2014-07-18T11:58:36Z
dc.date.issued2008-09-03
dc.date.updated2014-07-18T11:58:37Z
dc.description.abstractSeveral analogs of the cytotoxic thiopeptide IB-01211 or Mechercharmycin A (1) have been synthetized. The cytotoxicity of 1 and the synthetized analogs was evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives, 2 and 3c, were chosen for further studies like effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis was detected.
dc.format.extent9 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec564958
dc.identifier.issn0022-2623
dc.identifier.urihttps://hdl.handle.net/2445/56045
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1021/jm800513w
dc.relation.ispartofJournal of Medicinal Chemistry, 2008, vol. 51, num. 18, p. 5722-5730
dc.relation.urihttp://dx.doi.org/10.1021/jm800513w
dc.rights(c) American Chemical Society , 2008
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationCompostos heterocíclics
dc.subject.classificationMedicaments antineoplàstics
dc.subject.classificationSíntesi de pèptids
dc.subject.classificationEspectroscòpia de ressonància magnètica nuclear
dc.subject.otherHeterocyclic compounds
dc.subject.otherAntineoplastic agents
dc.subject.otherPeptide synthesis
dc.subject.otherNuclear magnetic resonance spectroscopy
dc.titleSynthesis and antitumor activity of mechercharmycin A analogues
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)