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Article

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Accepted version

Publication date

2008-09-03

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/56045

Synthesis and antitumor activity of mechercharmycin A analogues

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http://dx.doi.org/10.1021/jm800513w

Abstract

Several analogs of the cytotoxic thiopeptide IB-01211 or Mechercharmycin A (1) have been synthetized. The cytotoxicity of 1 and the synthetized analogs was evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives, 2 and 3c, were chosen for further studies like effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis was detected.

Subject

Compostos heterocíclics, Medicaments antineoplàstics, Síntesi de pèptids, Espectroscòpia de ressonància magnètica nuclear

Subject (English)

Heterocyclic compounds, Antineoplastic agents, Peptide synthesis, Nuclear magnetic resonance spectroscopy

Citation

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Citation

HERNÁNDEZ ROMERO, Delia, et al. Synthesis and antitumor activity of mechercharmycin A analogues. Journal of Medicinal Chemistry. 2008. Vol. 51, num. 18, pags. 5722-5730. ISSN 0022-2623. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/56045

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