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Article

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2015-04-21

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/172893

Fibrinogen-Derived γ377-395 Peptide Improves Cognitive Performance and Reduces Amyloid-β Deposition, without Altering Inflammation, in AβPP/PS1 Mice

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https://doi.org/10.3233/JAD-142928

Abstract

Fibrinogen has emerged as a promising therapeutic target against Alzheimer's disease because of its dual role in altered vascular function and amyloid-β aggregation. Here we provide evidence regarding cognitive improvement and reduction of brain parenchyma amyloid-β deposition in AβPP/PS1 mice after treatment for one month with the fibrinogen-blocking peptide Fibγ377-395. No alteration in glial response or other neuroinflammatory markers was observed in the cortex of treated animals. Considering these results and the fact that Fibγ377-395 does not affect coagulation function, this peptide could be considered as a promising and safe candidate for chronic treatment of Alzheimer's disease.

Subject

Ratolins (Animals de laboratori), Malaltia d'Alzheimer, Amiloïdosi, Fibrinogen, Inflamació

Subject (English)

Mice (Laboratory animals), Alzheimer's disease, Amyloidosis, Fibrinogen, Inflammation

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

ASO PÉREZ, Ester, et al. Fibrinogen-Derived γ377-395 Peptide Improves Cognitive Performance and Reduces Amyloid-β Deposition, without Altering Inflammation, in AβPP/PS1 Mice. Journal of Alzheimer's Disease. 2015. Vol. 47, num. 2, pags. 403-412. ISSN 1387-2877. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/172893

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