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Pregabalin in the treatment of inferior alveolar nerve paraesthesia following overfilling of endodontic sealer
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A case of orofacial pain and inferior alveolar nerve (IAN) paraesthesia after extrusion of endodontic sealer within the mandibular canal treated with prednisone and pregabalin is described. A 36-year-old woman underwent root canal treatment of the mandibular second right premolar tooth. Post-operative panoramic radiograph revealed the presence of radiopaque canal sealer in the mandibular canal. Damage to IAN consecutive to extrusion of endodontic sealer was diagnosed. Non-surgical management was decided, including: 1 mg/kg/day prednisone 2 times/day, once-daily regimen, and 150 mg/day pregabalin, two doses per day, monitoring the progress with periodic follow-up visits. Six weeks after the incident the signs and symptoms were gone. The complete resolution of paraesthesia and the control of pain achieved suggest that a non-surgical approach, combining prednisone and the GABA analogue pregabalin, is a good option in the management of the IAN damage subsequent to endodontic sealer extrusion
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ALONSO EZPELETA, Oscar, MARTÍN, Pablo j., LÓPEZ LÓPEZ, José, CASTELLANOS COSANO, Lizett, MARTÍN GONZÁLEZ, Jenifer, SEGURA EGEA, Juan josé. Pregabalin in the treatment of inferior alveolar nerve paraesthesia following overfilling of endodontic sealer. _Journal of Clinical and Experimental Dentistry_. 2014. Vol. 6, núm. 2, pàgs. 197-202. [consulta: 25 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/62779]