Files

166476.pdf (812.78 KB)

Document type

Article

Version

Accepted version

Publication date

2013-11-30

All rights reserved

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/226636

Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patients

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1016/j.pscychresns.2013.06.008

Abstract

Although working memory is known to be impaired in schizophrenia the anatomical and functional relationships underlying this deficit remain to be elucidated. A combined imaging approach involving functional and structural magnetic resonance techniques was used, applying independent component analysis and surface-based morphometry to 14 patients with schizophrenia and 14 healthy controls. Neurocognitive functioning was assessed by a neuropsychological test battery that measured executive function. It was hypothesized that working memory dysfunctional connectivity in schizophrenia is related to underlying anatomical abnormalities. Patients with schizophrenia showed cortical thinning in the left inferior frontal gyrus and insula, which explained 57% of blood oxygenation level-dependent signal magnitude in functional magnetic resonance imaging in the central executive network (lateral prefrontal and parietal cortex) over-activation and default mode network (anterior and posterior cingulate) deactivation. No structure-function relationship emerged in the healthy control group. The study provides evidence to suggest that dysfunctional activation/deactivation patterns in schizophrenia may be explained in terms of underlying gray matter deficits.

Subject

Esquizofrènia, Localitzacions cerebrals, Neuropsicologia

Subject (English)

Schizophrenia, Localization of cerebral functions, Neuropsychology

Citation

Collections

Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

PUJOL, Núria, et al. Inferior frontal and insular cortical thinning is related to dysfunctional brain activation/deactivation during working memory task in schizophrenic patients. Psychiatry Research-Neuroimaging. 2013. Vol. 214, num. 2, pags. 94-101. ISSN 0925-4927. [consulted: 6 of June of 2026]. Available at: https://hdl.handle.net/2445/226636

Export metadata

JSON - METS

Share record