Miniatura

Fitxers

728133.pdf (284.16 KB)

Tipus de document

Article

Versió

Versió acceptada

Data de publicació

2012-05-03

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/193825

HOMA-IR and non-HDL-C as predictors of high cholesteryl ester transfer protein activity in patients at risk for type 2 diabetes

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1016/j.clinbiochem.2012.02.005

Resum

Background and aims: Metabolic syndrome (MS) and type 2 diabetes are highly associated with an abnormal lipoprotein profile, which may be generated and accentuated by high cholesteryl ester transfer protein (CETP) activity. Given the difficulty in measuring CETP activity, the aim was to identify simple biochemical predictors of high CETP activity. Design and methods: Eighty five subjects at risk for type 2 diabetes were classified according to the presence of MS. Lipoprotein profile, HOMA-IR and endogenous CETP activity were evaluated. Results: As expected, MS patients presented higher concentration of glucose, insulin, triglycerides and non-HDL-C and lower HDL-C levels. Moreover, MS patients exhibited increased HOMA-IR and CETP activity. Employing a ROC curve for MS, high CETP activity was defined as >250%ml⁻¹ h⁻¹. The predictive variables of high CETP were non-HDL-C≥160mg/dl (OR=11.1;95%IC=3.3-38.2;p<0.001) and HOMA-IR>2.1 (OR=4.4;95%IC=1.3-14.8;p<0.05). Conclusions: High non-HDL-C and insulin resistance were predictors for increased CETP activity which measurement is not accessible for clinical laboratories.

Matèries

Diabetis, Colesterol

Matèries (anglès)

Diabetes, Cholesterol

Citació

Col·leccions

Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

Citació

CONIGLIO, R. i., MEROÑO, Tomás, MONTIEL, H, MALASPINA, M. m., SALGUEIRO, A. m., OTERO, J. c., FERRARIS, R., SCHREIER, L., BRITES, Fernando, GOMEZ ROSSO, Leonardo. HOMA-IR and non-HDL-C as predictors of high cholesteryl ester transfer protein activity in patients at risk for type 2 diabetes. _Clinical Biochemistry_. 2012. Vol. 45, núm. 7, pàgs. 566-570. [consulta: 24 de gener de 2026]. ISSN: 0009-9120. [Disponible a: https://hdl.handle.net/2445/193825]

Exportar metadades

JSON - METS

Compartir registre