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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/110002
P-Stereogenic bisphosphines with a hydrazine backbone: from N-N atropoisomerism to double nitrogen inversion
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The synthesis of P-stereogenic bisphosphine ligands starting from a phosphinous acid chiral synthon and hydrazine is reported. The dialkylation of the hydrazine backbone yielded atropo- and nitrogeninversion isomers which are in slow exchange. The crystallization of one of the isomers allowed us to study the reaction kinetics of the equilibria. The new ligands were tested in the Rh catalysed asymmetric hydrogenation of various benchmark substrates attaining up to 99% ee.
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PRADES, Amparo, et al. P-Stereogenic bisphosphines with a hydrazine backbone: from N-N atropoisomerism to double nitrogen inversion. Chemical Communications. 2017. Vol. 53, num. 4605-4608. ISSN 1359-7345. [consulted: 16 of June of 2026]. Available at: https://hdl.handle.net/2445/110002