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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/152583
Low-density lipoprotein (LDL)-antioxidant biflavonoids from Garcinia madruno
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Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu2+, was studied by means of a TBARS assay. The antioxidant potential of a biflavonoid fraction (BF) was also evaluated and correlated with its biflavonoid content. The flavanone-(3→8'')-flavone biflavonoids displayed antioxidant activity, particularly morelloflavone, which was significantly more potent than quercetin, with a CE50 of 12.36 μg/mL. Lipid peroxidation, was also significantly reduced in the presence of the BF (EC50 = 11.85 μg/mL). These results suggest that the BF is an excellent antioxidant.
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OSORIO DURANGO, Edison javier, LONDOÑO, Julián, BASTIDA ARMENGOL, Jaume. Low-density lipoprotein (LDL)-antioxidant biflavonoids from Garcinia madruno. _Molecules_. 2013. Vol. 18, núm. 5, pàgs. 6092-6100. [consulta: 24 de febrer de 2026]. ISSN: 1420-3049. [Disponible a: https://hdl.handle.net/2445/152583]