Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/177973
Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Background: the inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. Methods: retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish SEMI-COVID-19 Registry. The three categories of low, intermediate, and high risk were determined by taking into consideration the terciles of the total lymphocyte count and the values of C-reactive protein, lactate dehydrogenase, ferritin, and D-dimer taken at the time of admission. Results: a total of 17,122 patients were included in the study. The high-risk group was older (57.9 vs. 64.2 vs. 70.4 years; p < 0.001) and predominantly male (37.5% vs. 46.9% vs. 60.1%; p < 0.001). They had a higher degree of dependence in daily tasks prior to admission (moderate-severe dependency in 10.8% vs. 14.1% vs. 17%; p < 0.001), arterial hypertension (36.9% vs. 45.2% vs. 52.8%; p < 0.001), dyslipidemia (28.4% vs. 37% vs. 40.6%; p < 0.001), diabetes mellitus (11.9% vs. 17.1% vs. 20.5%; p < 0.001), ischemic heart disease (3.7% vs. 6.5% vs. 8.4%; p < 0.001), heart failure (3.4% vs. 5.2% vs. 7.6%; p < 0.001), liver disease (1.1% vs. 3% vs. 3.9%; p = 0.002), chronic renal failure (2.3% vs. 3.6% vs. 6.7%; p < 0.001), cancer (6.5% vs. 7.2% vs. 11.1%; p < 0.001), and chronic obstructive pulmonary disease (5.7% vs. 5.4% vs. 7.1%; p < 0.001). They presented more frequently with fever, dyspnea, and vomiting. These patients more frequently required high flow nasal cannula (3.1% vs. 4.4% vs. 9.7%; p < 0.001), non-invasive mechanical ventilation (0.9% vs. 3% vs. 6.3%; p < 0.001), invasive mechanical ventilation (0.6% vs. 2.7% vs. 8.7%; p < 0.001), and ICU admission (0.9% vs. 3.6% vs. 10.6%; p < 0.001), and had a higher percentage of in-hospital mortality (2.3% vs. 6.2% vs. 23.9%; p < 0.001). The three risk categories proved to be an independent risk factor in multivariate analyses. Conclusion: the present study identifies three risk categories for the requirement of high flow nasal cannula, mechanical ventilation, ICU admission, and in-hospital mortality based on lymphopenia and inflammatory parameters.
Matèries
Citació
Citació
RUBIO-RIVAS, Manuel, CORBELLA, Xavier, FORMIGA PÉREZ, Francesc, MENÉNDEZ FERNÁNDEZ, Estela, MARTÍN ESCALANTE, María dolores, BAÑOS FERNÁNDEZ, Isolina, ARNALICH FERNÁNDEZ, Francisco, CORRAL-BEAMONTE, Esther del, LALUEZA, Antonio, PARRA VIRTO, Alejandro, ROY VALLEJO, Emilia, LOUREIRO AMIGO, José, ÁLVAREZ SUÁREZ, Ana maría, ABADÍA-OTERO, Jesica, NAVARRO DE LA CHICA, María, ESTÉVEZ GONZÁLEZ, Raquel, HERNÁNDEZ MILIÁN, Almudena, ARESES MANRIQUE, María, BLÁZQUEZ ENCINAR, Julio césar, GONZÁLEZ NOYA, Amara, GONZÁLEZ FERRER, Ruth, PÉREZ AGUILERA, María, GIL SÁNCHEZ, Ricardo, MILLÁN NÚÑEZ-CORTÉS, Jesús, CASAS ROJO, José, SEMI-COVID-19 Network. Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry. _Journal of Clinical Medicine_. 2021. Vol. 10, núm. 10, pàgs. 2214. [consulta: 27 de gener de 2026]. ISSN: 2077-0383. [Disponible a: https://hdl.handle.net/2445/177973]