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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/194890
Optical control of adenosine-mediated pain modulation
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Adenosine receptors (ARs) play many important roles in physiology and have been recognized as potential targets for pain relief. Here, we introduce three photoswitchable adenosine derivatives that function as light-dependent agonists for ARs and confer optical control to these G protein-coupled receptors. One of our compounds, AzoAdenosine-3, was evaluated in the classical formalin model of pain. The molecule, active in the dark, was not metabolized by adenosine deaminase and effectively reduced pain perception in a light-dependent manner. These antinociceptive effects suggested a major role for A1R and A3R in peripheralmediated pain sensitization, whereas an average adenosine-mediated antinociceptive effect will be facilitated by A2AR and A2BR. Our results demonstrate that a photoswitchable adenosine derivative can be used to map the contribution of ARs mediating analgesia in vivo.
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HÜLL, Katharina, et al. Optical control of adenosine-mediated pain modulation. Bioconjugate Chemistry. 2021. Vol. 32, num. 9, pags. 1-5. ISSN 1043-1802. [consulted: 16 of October of 2026]. Available at: https://hdl.handle.net/2445/194890