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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/194890
Optical control of adenosine-mediated pain modulation
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Adenosine receptors (ARs) play many important roles in physiology and have been recognized as potential targets for pain relief. Here, we introduce three photoswitchable adenosine derivatives that function as light-dependent agonists for ARs and confer optical control to these G protein-coupled receptors. One of our compounds, AzoAdenosine-3, was evaluated in the classical formalin model of pain. The molecule, active in the dark, was not metabolized by adenosine deaminase and effectively reduced pain perception in a light-dependent manner. These antinociceptive effects suggested a major role for A1R and A3R in peripheralmediated pain sensitization, whereas an average adenosine-mediated antinociceptive effect will be facilitated by A2AR and A2BR. Our results demonstrate that a photoswitchable adenosine derivative can be used to map the contribution of ARs mediating analgesia in vivo.
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HÜLL, Katharina, FERNÁNDEZ DUEÑAS, Víctor, SCHÖNBERGER, Matthias, LÓPEZ-CANO, Marc, TRAUNER, Dirk, CIRUELA ALFÉREZ, Francisco. Optical control of adenosine-mediated pain modulation. _Bioconjugate Chemistry_. 2021. Vol. 32, núm. 9, pàgs. 1-5. [consulta: 21 de gener de 2026]. ISSN: 1043-1802. [Disponible a: https://hdl.handle.net/2445/194890]