Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study

Vista senzilla d'ítem
dc.contributor.authorCai, Lina
dc.contributor.authorWheeler, Eleanor
dc.contributor.authorKerrison, Nicola D.
dc.contributor.authorLuan, Jian’an
dc.contributor.authorDeloukas, Panos
dc.contributor.authorFranks, Paul W.
dc.contributor.authorAmiano, Pilar
dc.contributor.authorArdanaz, Eva
dc.contributor.authorBonet Bonet, Catalina
dc.contributor.authorFagherazzi, Guy
dc.contributor.authorGroop, Leif C.
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorHuerta Castaño, José María
dc.contributor.authorMasala, Giovanna
dc.contributor.authorNilsson, Peter M.
dc.contributor.authorOvervad, Kim
dc.contributor.authorPala, Valeria
dc.contributor.authorPanico, Salvatore
dc.contributor.authorRodriguez Barranco, M
dc.contributor.authorRolandsson, Olov
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorSpijkerman, Annemieke M. W.
dc.contributor.authorTjønneland, Anne
dc.contributor.authorTumino, Rosario
dc.contributor.authorvan der Schouw, Yvonne T.
dc.contributor.authorSharp, Stephen J.
dc.contributor.authorForouhi, Nita G.
dc.contributor.authorRiboli, Elio
dc.contributor.authorMcCarthy, Mark I.
dc.contributor.authorBarroso, Inês
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorWareham, Nicholas J.
dc.date.accessioned2021-02-09T09:27:22Z
dc.date.available2021-02-09T09:27:22Z
dc.date.issued2020-11-13
dc.date.updated2021-02-08T10:16:02Z
dc.description.abstractType 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of the largest prospective studies of T2D. Established as a nested case-cohort study to investigate the interplay between genetic and lifestyle behavioural factors on the risk of T2D, a total of 12,403 individuals were identified as incident T2D cases, and a representative sub-cohort of 16,154 individuals was selected from a larger cohort of 340,234 participants with a follow-up time of 3.99 million person-years. We describe the results from a genome-wide association analysis between more than 8.9 million SNPs and T2D risk among 22,326 individuals (9,978 cases and 12,348 non-cases) from the EPIC-InterAct study. The summary statistics to be shared provide a valuable resource to facilitate further investigations into the genetics of T2D.
dc.format.extent6 p.
dc.format.mimetypeapplication/pdf
dc.identifier.pmid33188205
dc.identifier.urihttps://hdl.handle.net/2445/173757
dc.language.isoeng
dc.publisherNature Research
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/s41597-020-00716-7
dc.relation.ispartofScientific Data, 2020, vol. 7
dc.relation.urihttps://doi.org/10.1038/s41597-020-00716-7
dc.rightscc by (c) Cai et al., 2020
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationDiabetis
dc.subject.classificationMalalties cardiovasculars
dc.subject.classificationMortalitat
dc.subject.otherDiabetes
dc.subject.otherCardiovascular diseases
dc.subject.otherMortality
dc.titleGenome-wide association analysis of type 2 diabetes in the EPIC-InterAct study
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

Fitxers

Paquet original

Mostrant 1 - 1 de 1
Miniatura
Nom:
CaiLN.pdf
Mida:
1.09 MB
Format:
Adobe Portable Document Format
Descarregar

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))